바소프레신과 데스모프레신이 가토 음경해면체 평활근의 수축 및 이완에 미치는 영향
The Effects of Vasopressin and Desmopressin on the Contractile and Relaxation Responses of Rabbit Cavernosal Smooth Muscle
신형오, 명순철, 김세철, 이무열,
소속 상세정보
신형오 ( Shin Hyung-Oh )
중앙대학교 의과대학 비뇨기과학교실
명순철 ( Myung Soon-Chul )
중앙대학교 의과대학 비뇨기과학교실
김세철 ( Kim Sae-Chul )
중앙대학교 의과대학 비뇨기과학교실
이무열 ( Lee Moo-Yeol )
중앙대학교 의과대학 생리학교실
KMID : 0358320080490040366
Abstract
Purpose : This study aimed to investigate the effects of vasopressin and desmopressin on the contractile and relaxative responses of rabbit cavernosal smooth muscle.
Materials & Methods : Isometric tension studies were conducted to investigate the effects of vasopressin(10?14-10?8M) and desmopressin(10?14- 10?8M) on the contraction and relaxation responses of rabbits cavernous muscle strips in an organ bath. The effects of pretreatment with phenylephrine(10?5M), L-NAME(10?5M) and indomethacin(10?5M) on the contraction and relaxation responses of the vasopressin and desmopressin were also investigated. The statistics were analyzed by Student’s t-test and ANOVA.
Results : Vasopressin contracted the strips in a dose-dependent manner, while desmopressin did not. The phenylephrine-induced contraction was dose-dependently increased by vasopressin, but it was dose-dependently relaxed by desmopressin. L-NAME pre-treatment did not block the relaxation response, but indomethacin pre-treatment did. Vasopressin- induced contraction occurred the via V1 receptor, while desmopressin- induced relaxation occurred via the V2 receptor.
Conclusion : Vasopressin, in pathophysiological circumstances, would worsen erectile dysfunction. On the contrary, desmopressin, which may induce an endothelium-dependent relaxation of the cavernous smooth muscles, would be good for erectile function. (Korean J Urol 2008;49: 366-372)
키워드
Vasopressins; Desmopressin; Cavernosal smooth muscle; Contraction; Relaxation
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