Dutasteride의 단기 복용이 전립선비대에서 미세혈관밀도에 미치는 영향
The Effect of Short Term Dutasteride Therapy on Microvessel Density in Benign Prostatic Hyperplasia
우제형, 강정윤, 김은경, 유탁근,
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우제형 ( Woo Jea-Hyung )
을지대학교 의과대학 을지병원 비뇨기과학교실
강정윤 ( Kang Jung-Yoon )
을지대학교 의과대학 을지병원 비뇨기과학교실
김은경 ( Kim Eun-Kyung )
을지대학교 의과대학 병리학교실
유탁근 ( Yoo Tag-Keun )
을지대학교 의과대학 을지병원 비뇨기과학교실
KMID : 0358320080490060515
Abstract
Purpose: Several studies have shown that finasteride limits hematuria in patients with benign prostatic hyperplasia(BPH). However, there are few reports addressing dutasteride therapy. We evaluated the effect of dutasteride on intraoperative blood loss and on microvessel density(MVD) in patients with BPH.
Material and Methods : We studied 39 patients with BPH who underwent transurethral resection of the prostate(TURP). Group I included 22 patients who received dutasteride 0.5mg daily for 2 weeks preoperatively, and group II included 17 patients who did not. Blood loss was evaluated by comparing preoperative and postoperative hemoglobin. Sections from the prostatic suburothelium and hyperplastic prostate were individually stained for CD 34. MVD was calculated by counting the number of positively stained blood vessels in 5 random high power fields. There were no significant differences between the groups in terms of age, total prostatic volume, resected prostatic weight, or prostate-specific antigen (PSA).
Results:The mean MVD in the suburethral portion in dutasteride-treated patients was significantly lower than that seen in untreated patients(14.47 versus 22.19 vessels per high power field, p=0.026). In nodular hyperplasia, there was no significant difference in MVD between the two group(14.72 versus 15.24 vessels per high power field, p=0.801).
Conclusion:Short term pretreatment with dutasteride decreases suburethral prostatic MVD in patients with BPH and may help reduce blood loss during TURP, particularly in huge BPH, which sometimes bleeds excessively during operation.
키워드
Microvessel density;Dutasteride;Benign prostatic;hyperplasia
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