N-butyl-N-(4-hydroxybutyl) Nitrosamine으로 유발시킨 쥐의 방광암에서 Magnolia officinalis 추출물의 항암효과
Anticancer Effect of Magnolia officinalis’ Extract on N-butyl-N-(4-hydroxybutyl) Nitrosamine Induced Bladder Cancer in Mice
이승찬, 정필두, 김용준, 윤석중, 이상철, 김원재,
소속 상세정보
이승찬 ( Lee Seung-Chan )
Chungbuk National University
정필두 ( Jung Pil-Du )
Chungbuk National University
김용준 ( Kim Yong-June )
Chungbuk National University
윤석중 ( Yun Seok-Joong )
Chungbuk National University
이상철 ( Lee Sang-Cheol )
Chungbuk National University
김원재 ( Kim Wun-Jae )
Chungbuk National University
KMID : 0358320080490080682
Abstract
Purpose: Magnolia officinalis has been used in traditional Chinese medicine to treat a variety of diseases. The main constituents of Magnolia officinalis are honokiol and magnolol, which have a variety of pharmacological effects, such as antitumor, antioxidant, antimicrobial, anti-inflammatory etc. This study examined the anticancer effect of a Magnolia officinalis’ extract on urinary bladder cancer in vivo. Materials and
Methods: Male mice C3H/He were used as the experimental animals. The mice were divided into ten groups. Normal drinking water was provided to group 1(5 mice) for 20 weeks and 0.05% N-butyl- N-(4-hydroxybutyl) nitrosamine(BBN) was added to in the drinking water of group 2(5 mice). 0.1, 0.3, 1.0 and 3.0% Magnolia officinalis’ extract was added to groups 3, 4, 5 and 6, respectively(5 mice each), and 0.1, 0.3, 1.0 and 3.0% Magnolia officinalis’ extract plus 0.05% BBN was added to groups 7, 8, 9 and 10, respectively(10 mice each) for the same period. All surviving mice were sacrificed at week 20 to investigate the occurrence of bladder cancer, stage and grade.
Results: Bladder cancer was not observed in groups 1, 3, 4, 5 and 6 mice. The rates of bladder cancer occurrence were 57.1, 66.7, 44.4 and 20.0% in groups 7, 8, 9 and 10, respectively. The incidence decreased with increasing concentration of Magnolia officinalis (p=0.005). However, the stage and grade were not associated with the concentration of Magnolia officinalis(each p＞0.05).
Conclusions: This study showed that Magnolia officinalis has some protective effect against bladder cancer. In the future, Magnolia officinalis may be expected to play an important role as a chemo-preventive and therapeutic agent or as a complementary agent in bladder cancer. (Korean J Urol 2008;49:682-687)
키워드
Magnolia officinalis;Bladder cancer;N-butyl-N-(4-hydroxybutyl) nitrosamine
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