인체 방광이행상피세포암의 임상병리학적 특성과 Clusterin 및 Ki-67 발현과의 관계
The Relationship of Clusterin Expression and Ki-67 Labeling Index with Clinicopathologic Factors in Human Transitional Cell Carcinoma
천원희, 이상돈, 이정주, 최경운,
소속 상세정보
천원희 ( Chon Won-Hee )
부산대학교 의과대학 비뇨기과학교실
이상돈 ( Lee Sang-Don )
부산대학교 의과대학 비뇨기과학교실
이정주 ( Lee Jeong-Zoo )
부산대학교 의과대학 비뇨기과학교실
최경운 ( Choi Kyung-Un )
부산대학교 의과대학 병리학교실
KMID : 0358320080490080688
Abstract
Purpose: This study examined the expression of clusterin and Ki-67 in human transitional cell carcinoma(TCC). In addition, the relationship of clusterin and Ki-67 expression with the clinicopathological factors and prognosis of human TCC was investigated. Materials and
Methods: 149 human TCC tissues were obtained from 149 patients who underwent a radical cystectomy(n=81) or transurethral resection(n=68). The expression of clusterin and Ki-67 was analyzed using immunohistochemical staining. The results were evaluated with respect to the clinicopathological factors.
Results: Positive clusterin expression was observed in 21.1% of the total TCC tissues. The expression of clusterin was not significantly related to age, gender, tumor stage and grade. However, recurrence-free survival rate of the patients with positive clusterin expression was significantly lower than that of patients with negative clusterin expression(p=0.02). The expression level of Ki-67 in the TCC tissues was associated with the tumor stage(p＜0.001) and grade(p＜0.001), but not with age and gender. Furthermore, the recurrence-free survival rate of patients with strong Ki-67 expression was significantly lower than that of patients with weak Ki-67 expression(p＜0.001). The expression of clusterin was not significantly related to the level of Ki-67 expression. However, in the patients showing strong Ki-67 expression, the recurrence-free survival rate of the patients with positive clusterin expression was significantly lower than that of the patients with negative clusterin expression(p＜0.001).
Conclusions: These results suggest that the expression of clusterin and Ki-67 can be used as a useful predictor of the prognosis of patients with human TCC. (Korean J Urol 2008;49:688-695)
키워드
Transitional cell carcinoma;Clusterin;Ki67
원문 및 링크아웃 정보
등재저널 정보