확대 전립선 생검을 통해 저위험성으로 확인된 국소전립선암의 근치적 전립선적출술 후 병리학적 결과
Pathologic Outcome of Unilateral Low Risk Prostate Cancers on Multicore Prostate Biopsy after Radical Prostatectomy
정재승, 한병규, 정성진, 홍성규, 이상은, 최기영,
소속 상세정보
정재승 ( Chung Jae-Seung )
포천중문의과대학교 비뇨기과학교실
한병규 ( Han Byoung-Kyu )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
정성진 ( Jeong Seong-Jin )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
홍성규 ( Hong Sung-Kyu )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
이상은 ( Lee Sang-Eun )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
최기영 ( Choi Ghee-Young )
서울대학교 의과대학 분당서울대학교병원 병리과학교실
KMID : 0358320080490100874
Abstract
Purpose: To investigate clinicopathologic characteristics of unilateral, low risk prostate cancers detected via multi(≥12)-core prostate biopsy.
Materials and Methods: One hundred four patients who underwent radical retropubic prostatectomy(RRP) for unilateral, low risk prostate cancer (clinical stage ≤T2a, biopsy Gleason sum ≤6, PSA ≤10ng/ml, and ipsilateral positive cores ≤2) detected via multi (≥12)-core prostate biopsy were enrolled. In this retrospective study, we reviewed the patients’ preoperative and pathologic data to assess potential predictors of pT2c or greater disease at the time of RRP, as well as characteristics of such disease.
Results: Of the 104 subjects, only 34(32.7%) were pathologically-proven to have unilateral disease, while the others showed pathologically-bilateral or worse disease from analysis of the RRP specimens. Subjects pathologically found to have uni- and bi-lateral disease showed no significant differences regarding age, prostate-specific antigen(PSA), free-to-total PSA ratio, prostate volume, clinical stage, number of positive cores, biopsy Gleason score, number of total biopsy sites, and highest percentage of tumor at any biopsy site. Multivariate logistic regression analysis revealed no significant preoperative predictors of pT2c or greater disease at RRP.
Conclusions: Most patients with unilateral, low risk prostate cancer detected on multi(≥12)-core prostate biopsy actually had pathologically- worse disease. For clinically-localized prostate cancer, a more accurate method to identify appropriate candidates for unilateral or focal ablative therapy should be developed.
키워드
Prostate;Prostate cancer;Biopsy;Prostatectomy
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