근치적 전립선적출술 후 생화학적 재발의 예측인자로 Epidermal Growth Factor Receptor의 발현: 전향적 연구
Epidermal Growth Factor Receptor as Predicting Factor on Biochemical Recurrence after Radical Prostatectomy: A Prospective Study
이정우, 정재영, 한경석, 서호경, 정진수, 이강현, 박원서, 조강수, 김은경,
소속 상세정보
이정우 ( Lee Jeong-Woo )
서울대학교 의과대학 비뇨기과학교실
정재영 ( Jeong Jae-Young )
국립암센터 비뇨기과
한경석 ( Han Kyung-Seok )
국립암센터 비뇨기과
서호경 ( Seo Ho-Kyung )
국립암센터 비뇨기과
정진수 ( Chung Jin-soo )
국립암센터 비뇨기과
이강현 ( Lee Kang-Hyun )
국립암센터 비뇨기과
박원서 ( Park Weon-Seo )
국립암센터 병리과
조강수 ( Cho Kang-Su )
국립암센터 비뇨기종양클리닉
김은경 ( Kim Eun-Kyoung )
국립암센터 비뇨기종양클리닉
KMID : 0358320080490110974
Abstract
Purpose: We investigated epidermal growth factor receptor(EGFR) expression in prostate cancer(PCa) and their potential role as predicting factor on biochemical recurrence(BCR).
Materials and Methods: Between February 2005 and February 2007, EGFR expression were prospectively evaluated in a consecutive series of 88 PCa patients with the following characteristics: 66 patients treated with retropubic radical prostatectomy(RRP); 22 patients treated with neoadjuvant hormonal therapy followed by RRP. The relationship between EGFR expression and several clinicopathologic parameters were evaluated. The probability of BCR-free survival was determined using the Kaplan-Meier method.
Results: EGFR expression, was evaluated by immunohistochemistry, was found in 31 of 88(35.2%) patients. 8 of 31 EGFR-positive patients(25.8%) had BCR, whereas only 5 of 57 EGFR-negative patients(8.8%) had BCR (p=0.031) during a median follow-up of 21 months. Among several variables, high serum prostate-specific antigen values(≥20), extraprostatic extension, seminal vesicle invasion, and EGFR expression were the significant predictors of BCR on univariate analysis. But, multivariate analysis showed that no variable was significant predictor of BCR. EGFR-negative patients had a significantly longer mean BCR-free survival time than EGFR-positive patients(p=0.027).
Conclusions: EGFR expression could be an potential predicting factor on BCR following RRP.
키워드
Epidermal growth factor receptor;Prostate cancer;Biochemical recurrence
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