표재성방광암에서 Survivin과 p53 발현의 임상적 의의
Clinical Implications of the Expression of Survivin and p53 in Superficial Transitional Cell Carcinoma of the Bladder
곽동윤, 장혁수, 박철희, 김천일, 하지용, 최미선,
소속 상세정보
곽동윤 ( Kyack Dong-Yoon )
계명대학교 의과대학 비뇨기과학교실
장혁수 ( Chang Hyuk-Soo )
계명대학교 의과대학 비뇨기과학교실
박철희 ( Park Choal-Hee )
계명대학교 의과대학 비뇨기과학교실
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
하지용 ( Ha Ji-Yong )
계명대학교 의과대학 비뇨기과학교실
최미선 ( Choe Mi-Sun )
계명대학교 의과대학 병리학교실
KMID : 0358320090500010012
Abstract
Purpose: The prognostic value of p53 remains controversial in transitional cell carcinomas of the bladder. Survivin, an inhibitor of apoptosis, is expressed in many human cancers. Recent studies have reported increased expression of survivin in superficial transitional cell carcinomas of the bladder. We investigated the expression of survivin and p53 and the clinical implications of this expression in superficial transitional cell carcinomas of the bladder.
Materials and Methods: Immunohistochemical staining of paraffin sections using a monoclonal antibody for survivin and p53 was performed in 82 cases of superficial transitional cell carcinomas of the bladder. Correlations between the expression of survivin and p53 and clinicopathological features, such as age, multiplicity of tumor, size, recurrence, and progression, were examined.
Results: Among 82 cases, positive survivin expression(greater than 20%) was observed in 59 cases. Positive p53 expression(greater than 20%) was observed in 46 cases. There were no significant differences in age, gender, multiplicity, tumor size, tumor grade, pT stage, recurrence, or progression-free survival between p53-positive and p53-negative groups(p＞0.05). Also, there were no significant differences in age, gender, multiplicity, tumor size, tumor grade, or pT stage between survivin-positive and survivinnegative groups(p＞0.05). However, recurrent-free and progression-free survivals were significantly lower in the survivin-positive group than in the survivin-negative group(p＜0.05).
Conclusions: The expression of survivin can be recommended as a useful marker for predicting disease recurrence and progression. Survivin may be superior to p53 as a prognostic factor in superficial transitional cell carcinoma of bladder.(Korean J Urol 2009;50:12-17)
키워드
Urinary bladder neoplasms;Human BIRC5 protein;p53 genes
원문 및 링크아웃 정보
등재저널 정보