발기부전 환자에서 홍삼농축분말의 유효성 및 안전성: 다기관, 무작위배정, 이중맹검, 위약 대조 임상연구
Efficacy and Safety of Red Ginseng Extract Powder in Patients with Erectile Dysfunction: Multicenter, Randomized, Double-Blind, Placebo-Controlled Study
함원식, 김원태, 이진선, 주희정, 강신정, 오진환, 허율, 정재용, 박광성, 최영득,
소속 상세정보
함원식 ( Ham Won-Sik )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
김원태 ( Kim Won-Tae )
연세대학교 의과대학 비뇨기과학교실
이진선 ( Lee Jin-Sun )
연세대학교 의과대학 비뇨기과학교실
주희정 ( Ju Hee-Jeong )
연세대학교 의과대학 비뇨기과학교실
강신정 ( Kang Shin-Jyung )
중부대학교 산학협력단
오진환 ( Oh Jin-Hwan )
중부대학교 산학협력단
허율 ( Her Youl )
중부대학교
정재용 ( Chung Jae-Yong )
메콕스큐어메드
박광성 ( Park Kwang-Sung )
전남대학교 의과대학 비뇨기과학교실
최영득 ( Choi Young-Deuk )
연세대학교 의과대학 비뇨기과학교실, 비뇨의과학연구소
KMID : 0358320090500020159
Abstract
Purpose: To evaluate the safety and efficacy of red ginseng extract powder (OKBT) for treating erectile dysfunction.
Materials and Methods: Sixty-nine adult patients with mild to moderate erectile dysfunction of various etiologies were randomized to receive placebo or red ginseng extract powder. The red ginseng extract powder used in the present study was named OKBT. The primary efficacy parameter was response to the International Index of Erectile Function (IIEF) erectile function domain at baseline and week 8. Other IIEF domain scores were evaluated as secondary parameters. For safety evaluation, we performed history taking, physical examination, clinical laboratory tests, and hormonal tests at baseline and week 8.
Results: There were no significant differences in the patients’ characteristics between the 2 groups. After 8 weeks of administration, primary efficacy (erectile function domain) and all secondary efficacy domains were significantly improved in the OKBT group compared with the placebo group (p＜0.05). Notably, even the domain related to sexual desire, frequency and degree of sexual desire, was also improved in the OKBT group (p＜0.001). There were no significant adverse reactions with OKBT administration, and there were also no significant differences in the results of laboratory tests between the 2 groups after administration.
Conclusions: Our data show that red ginseng extract powder can be used as an alternative remedy for Korean men suffering from mild to moderate erectile dysfunction.
키워드
Ginseng;Erectile dysfunction;Treatment efficacy
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