전립선특이항원 선별검사 도입에 따른 전립선암의 임상병리학적 특성의 변화
Changes in Prostate Cancer Pattern according to Prostate-Specific Antigen Screening Test
권종규, 장인호, 김태형, 명순철,
소속 상세정보
권종규 ( Kwon Jong-Kyou )
중앙대학교 의과대학 비뇨기과학교실
장인호 ( Chang In-Ho )
중앙대학교 의과대학 비뇨기과학교실
김태형 ( Kim Tae-Hyoung )
중앙대학교 의과대학 비뇨기과학교실
명순철 ( Myung Soon-Chul )
중앙대학교 의과대학 비뇨기과학교실
KMID : 0358320090500050439
Abstract
Purpose: The aim of this study was to investigate the changes in the clinical and prognostic parameters of prostate cancer in Korean men in the eras before and after prostate-specific antigen (PSA) testing.
Materials and Methods: The medical records of 303 patients treated for prostate cancer between 1982 and 2005 were reviewed with respect to age, chief complaints, clinical stage, tumor grade, treatment options, and prognosis. We classified the patients as follows: those treated in the pre- PSA era (1982-1995, n=81), and those treated in the PSA era (1996-2000, PSA era phase 1, n=92; and 2001-2005, PSA era phase 2, n=130).
Results: There was no significant difference in age or clinical stage between patients treated before and those treated during the PSA era, although there was a downward migration of grade. The cancer-specific survival rates were also not different in all cases and in metastatic prostate cancer cases between the pre-PSA era and the PSA era, although the overall survival rates were significantly greater in all cases in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p＜0.05). However, the cancer-specific survival rates for localized or locally advanced prostate cancer were significantly greater in phase 2 of the PSA era than in the pre-PSA era or in phase 1 of the PSA era (p＜0.05).
Conclusions: We observed a downward migration of tumor grade, but there were no migrations in the age of patients or clinical stage, and these findings have not contributed to changes in the cancer survival of Korean men with prostate cancer after the advent of PSA testing.
키워드
Prostatic neoplasms;Prostate-specific antigen;Mass screening;Survival rate
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