Adiponectin과 Leptin이 전립선암 세포의 증식에 미치는 영향
The Effects of Adiponectin and Leptin in the Proliferation of Prostate Cancer Cells
이소연, 박세준, 장인호, 명순철, 김태형,
소속 상세정보
이소연 ( Lee So-Yeon )
중앙대학교 의과대학 비뇨기과학교실
박세준 ( Park Se-Jun )
중앙대학교 의과대학 비뇨기과학교실
장인호 ( Chang In-Ho )
중앙대학교 의과대학 비뇨기과학교실
명순철 ( Myung Soon-Chul )
중앙대학교 의과대학 비뇨기과학교실
김태형 ( Kim Tae-Hyoung )
중앙대학교 의과대학 비뇨기과학교실
KMID : 0358320090500050493
Abstract
Purpose: With the westernization of dietary life, domestic prostate cancer prevalence has remarkably increased recently. Therefore, to examine the effects of obesity on prostate cancer, we analyzed the effects of leptin and adiponectin, which are the cytokines secreted from adipocytes, on prostate cancer in vitro and confirmed the results by in vivo experiment.
Materials and Methods: In vitro, the human androgen-independent prostate cancer cell line DU-145 was exposed to various concentrations of adiponectin and leptin, and their effects were measured with the 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In vivo, the effects of tumor growth were observed in xenografted nude mice with prostate cancer.
Results: Adiponectin significantly repressed DU-145 cell growth in a dose- dependent manner. Leptin promoted DU-145 cell growth in dose-dependent manner, but it was not significant statistically. In vivo, adiponectin- treated mice demonstrated a reduced tumor volume, although it was not significant statistically. By contrast, leptin-treated mice showed a significantly increased tumor volume (p＜0.01).
Conclusions: The in vitro and in vivo finding suggested that adiponectin suppresses the proliferation of prostate cancer cells and that leptin plays an important role in the proliferation of prostate cancer cells. We suggest that adiponectin and leptin have a relation to the progression of prostate cancer in the obese population.
키워드
Prostatic neoplasms;Adiponectin;Leptin
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