전립선생검 전 단기전립선특이항원속도 측정
Short-term Prostate-Specific Antigen Velocity Measurement before Prostate Biopsy
박종탁, 김세중, 안현수, 김영수, 최종보, 김선일,
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박종탁 ( Park Jong-Tak )
아주대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
안현수 ( Ahn Hyun-Soo )
아주대학교 의과대학 비뇨기과학교실
김영수 ( Kim Young-Soo )
아주대학교 의과대학 비뇨기과학교실
최종보 ( Choi Jong-Bo )
아주대학교 의과대학 비뇨기과학교실
김선일 ( Kim Sun-Il )
아주대학교 의과대학 비뇨기과학교실
KMID : 0358320090500060553
Abstract
Purpose: We investigated whether a short-term follow-up prostate-specific antigen (PSA) measurement before prostate biopsy is useful in predicting the presence of prostate cancer.
Materials and Methods: From January 2004 to May 2008, 670 patients underwent transrectal ultrasound-guided prostate biopsy. The initial PSA (PSA1) was measured at the first outpatient visit. The second PSA (PSA2) was measured the evening before prostate biopsy. Only the patients with a PSA1 between 2.5 and 20 ng/ml and an interval between PSA1 and PSA2 of between 7 and 90 days were included in this study. The short-term PSA velocity (PSAVm) was defined as {(PSA2?PSA1/interval (days)}x30. Prostate volume (PV), PSA1, PSA2, and PSAVm were compared between the patients with prostate cancer and those with benign histology.
Results: Of the 362 patients who fulfilled the entry criteria, 365 prostate biopsies were performed. The PSAVm differed significantly between patients with prostate cancer and those with benign histology (p=0.021). In patients with a PSA1 of 10-20 ng/ml, age, PV, PSA1, PSA2, and PSAVm were significantly different between patients with prostate cancer and those with benign histology, whereas in patients with a PSA1 of 2.5-10 ng/ml, only PV was significantly different. In multivariate logistic regression analysis excluding PSA1 and PSA2, PSAVm was a significant predictor of prostate cancer overall and in patients with a PSA1 of 10-20 ng/ml, but not in patients with a PSA1 of 2.5-10 ng/ml.
Conclusions: PSAVm was significantly different between the benign group and the prostate cancer group. But, this difference was mainly the result of a falsely elevated PSA, and PSAVm was not a significant predictor of prostate cancer when the PSA1 was 2.5-10 ng/ml.
키워드
Prostate-specific antigen;Biopsy;Prostatic neoplasms
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