만성세균성전립선염 흰쥐 모델에서 마늘 추출물의 염증 예방 및 항균, 항염 효과
Preventive Effect on Inflammation and Anti-Inflammatory and Anti-Microbial Effects of Garlic Extract in a Rat Model of Chronic Bacterial Prostatitis
김성인, 임승혁, 손동완, 이승주, 하유신, 한창희, 조용현,
소속 상세정보
김성인 ( Kim Sung-In )
가톨릭대학교 의과대학 비뇨기과학교실
임승혁 ( Yim Seung-Hyuk )
가톨릭대학교 의과대학 비뇨기과학교실
손동완 ( Sohn Dong-Wan )
가톨릭대학교 의과대학 비뇨기과학교실
이승주 ( Lee Seung-Ju )
가톨릭대학교 의과대학 비뇨기과학교실
하유신 ( Ha U-Syn )
가톨릭대학교 의과대학 비뇨기과학교실
한창희 ( Han Chang-Hee )
가톨릭대학교 의과대학 비뇨기과학교실
조용현 ( Cho Yong-Hyun )
가톨릭대학교 의과대학 비뇨기과학교실
KMID : 0358320090500060602
Abstract
Purpose: Garlic has anti-microbial and anti-inflammatory effects. We investigated its actions and preventive effects on chronic bacterial prostatitis (CBP) using a rat model.
Materials and Methods: Bacterial suspension was inserted into the prostatic urethra of 75 rats. Then 15 were grouped as garlic group, and 60 as control group. Garlic and saline were given to each group for 4 weeks, respectively. After partial resection of the prostate, microbiological culture and histological examination were done. The incidence of CBP was compared between two groups. To evaluate the anti-microbial and anti- inflammatory effect of garlic, the 41 rats proved as CBP models among the control group were divided into 4 groups randomly: I, control; II, garlic; III, ciprofloxacin; IV, garlic plus ciprofloxacin. After 3 weeks of treatment, microbiological cultures of urine, prostate and histological examination of prostate were done.
Results: In study of the preventive effects, 5 rats in garlic treatment group and 41 rats in control group were shown to be CBP models. In anti- microbial and anti-inflammatory evaluation, positive urine culture rate and prostate tissue show no significant difference among four groups, but bacterial growth in urine and prostate tissue were lower in groups II, III, and IV than group I. Bacterial growth was the slowest in prostate tissue of group IV. Histologic findings were more improved in groups II, III and IV than group I, with Group IV being the most improved.
Conclusions: These results show that garlic has preventive and therapeutic effects on CBP. Combination treatment with antibiotics may be considered in the future.
키워드
Garlic;Prostatitis
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