호르몬 불응성 전립선암 환자의 생존율 및 예후인자
Survival Rates and Related Factors in Men with Hormone-Refractory Prostate Cancer
하홍구, 윤창진, 이승수, 신동길, 이완, 이정주, 정문기,
소속 상세정보
하홍구 ( Ha Hong-Koo )
부산대학교 의학전문대학원 비뇨기과학교실
윤창진 ( Yun Chang-Jin )
부산대학교 의학전문대학원 비뇨기과학교실
이승수 ( Lee Seung-Soo )
부산대학교 의학전문대학원 비뇨기과학교실
신동길 ( Shin Dong-Gil )
부산대학교 의학전문대학원 비뇨기과학교실
이완 ( Lee Wan )
부산대학교 의학전문대학원 비뇨기과학교실
이정주 ( Lee Zeong-Zoo )
부산대학교 의학전문대학원 비뇨기과학교실
정문기 ( Chung Moon-Kee )
부산대학교 의학전문대학원 비뇨기과학교실
KMID : 0358320090500070649
Abstract
Purpose: We evaluated survival rate in patients with hormone-refractory prostate cancer (HRPC) and the clinical factors that influenced survival rate and time.
Materials and Methods: The medical records of 96 patients who had HRPC and were not treated with chemotherapy from 2000 to 2008 were reviewed. We evaluated the survival rates at the 1st, 3rd, and 5th year by using Kaplan-Meier survival curves. We also evaluated survival differences according to clinical variables (clinical T stage, Gleason score, nadir prostate-specific antigen [PSA], PSA doubling time, and PSA velocity) by using the log-rank test and the relations between survival rates and these variables by using Cox proportional hazards models.
Results: The mean age of the patients was 67.8±7.5 years and the mean follow-up period was 23.3±13.7 months. Cancer-specific survival rates at the 1st, 3rd, and 5th year were 57.8%, 16.8%, and 10.1%, respectively, and survival differences were significantly related to nadir PSA (p=0.002) and PSA velocity (p=0.019). In the univariate analysis, nadir PSA (p=0.004) and PSA velocity (p=0.024) were related to survival rate, but only nadir PSA remained as a significant variable for survival rate in patients with HRPC in the multivariate analysis (p=0.044).
Conclusions: Cancer-specific survival rates in patients with HRPC at the 1st, 3rd, and 5th year were 57.8%, 16.8%, and 10.1%, respectively, and they were related to nadir PSA. These results may be useful in determining a therapeutic approach in patients with HRPC.
키워드
Prostatic neoplasms; Survival; Risk factors
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