한국 성인남성에서 인체측정학적 인자 및 대사증후군 혈청학적 인자가 전립선특이항원에 미치는 영향
The Effects of Anthropometric Factors and Serologic Factors of the Metabolic Syndrome on Prostate-Specific Antigen Levels in Korean Men
함영일, 주관중, 박흥재,
소속 상세정보
함영일 ( Hahm Young-Il )
성균관대학교 의과대학 강북삼성병원 비뇨기과학교실
주관중 ( Joo Kwan-Joong )
성균관대학교 의과대학 강북삼성병원 비뇨기과학교실
박흥재 ( Park Heung-Jae )
성균관대학교 의과대학 강북삼성병원 비뇨기과학교실
KMID : 0358320090500070663
Abstract
Purpose: We evaluated the effects of anthropometric and serological parameters on serum prostate-specific antigen (PSA) in Korean men.
Materials and Methods: This study included 92,891 healthy Korean men who visited our health promotion center for a general health checkup. The mean age of the participants was 42.6 years (range, 20-77 years). Exclusion criteria were a serum PSA level over 4.0 ng/dl or pyuria on urinalysis (＞5 white blood cells/high power field). All participants were evaluated for several anthropometric factors (height, weight, systolic blood pressure, diastolic blood pressure, body mass index [BMI], body surface area [BSA], fat mass, body fat percentage, and lean body mass) and for serologic parameters including components of the metabolic syndrome (fasting blood sugar, triglyceride [TG], and high-density lipoprotein cholesterol) biochemically. We analyzed the relationship between serum PSA levels and the various anthropometric and serologic parameters.
Results: In the univariate analysis, serum PSA levels were significantly positively correlated with age and with low-density lipoprotein (LDL) cholesterol after adjustment for age. On the other hand, serum PSA levels were negatively correlated with height, weight, BMI, BSA, fat mass, body fat percentage, lean body mass, aspartate aminotransferase, alanine aminotransferase, and TG. In the multivariate analysis, age and LDL-cholesterol had positive correlations with serum PSA levels, but BMI, BSA, fat mass, lean body mass, and TG were negatively correlated with PSA levels.
Conclusions: These results suggest that the serum PSA level is significantly influenced by age, the components of metabolic syndrome (BMI, TG), and serologic parameters such as LDL-cholesterol. The normal range of serum PSA should be considered in association with metabolic syndrome and anthropometric factors as well as age.
키워드
Prostate-specific antigen; Body mass index; Body surface area; Metabolic syndrome
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