전립선암에 대한 근치적 전립선적출술 중 동결절편검사 양성의 술 전 예측 인자
The Preoperative Factors Predicting a Positive Frozen Section during Radical Prostatectomy for Prostate Cancer
심명선, 유창희, 정인갑, 김청수,
소속 상세정보
심명선 ( Shim Myung-Sun )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
유창희 ( Yoo Chang-Hee )
한림대학교 의과대학 비뇨기과학교실
정인갑 ( Jeong In-Gab )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
김청수 ( Kim Choung-Soo )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
KMID : 0358320090500080751
Abstract
Purpose: The purpose of this study was to identify the preoperative factors that predict a positive frozen section during radical prostatectomy for prostate cancer.
Materials and Methods: We retrospectively analyzed preoperative prostate-specific antigen (PSA), prostate volume, Gleason score, the number or percent (%) of cancer-positive cores from prostate biopsy, and the clinical stage of 364 patients who underwent radical prostatectomy between 1993 and 2007. We compared these parameters between patients who had positive frozen sections in specimens from the urethra or bladder neck with those who had negative frozen sections.
Results: The PSA and Gleason score were significantly higher and prostate volume was significantly smaller in patients with positive frozen sections in the urethra than in patients with negative frozen sections. The results were the same for the bladder neck. In multivariate analysis, PSA was the only independent predictor for positive frozen sections at the bladder neck, and the cutoff value was 8.71 ng/ml.
Conclusions: Preoperative PSA may be a potent factor for predicting positive frozen sections during radical prostatectomy, especially in the bladder neck. Therefore, it may be beneficial to prepare frozen sections of the bladder neck during the operation to reduce the positive resection margin when PSA is higher than 8.7 ng/ml.
키워드
Prostatectomy;Frozen sections;Prostatic neoplasms;Prostate- specific antigen
원문 및 링크아웃 정보
등재저널 정보