Gleason 점수 6 전립선암의 술 후 Upgrading 및 Upstaging을 예측하는 인자
Predictive Factors for Upgrading or Upstaging in Biopsy Gleason Score 6 Prostate Cancer
김성철, 홍준혁, 송강현, 정인갑, 송채린, 김청수, 안한종,
소속 상세정보
김성철 ( Kim Seong-Cheol )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
홍준혁 ( Hong Jun-Hyuk )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
송강현 ( Song Kang-Hyon )
원자력병원 비뇨기과
정인갑 ( Jeong In-Gab )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
송채린 ( Song Cheryn )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
김청수 ( Kim Choung-Soo )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
안한종 ( Ahn Han-Jong )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
KMID : 0358320090500090836
Abstract
Purpose: Although biopsy Gleason score (GS) 6 prostate cancers are expected to demonstrate a more indolent clinical course than those with GS 7 or higher cancers, substantial proportion reveal upgrading or upstaging on final pathology. We investigated predictive factors of upstaging or upgrading after radical prostatectomy (RP) in biopsy GS 6 prostate cancers.
Materials and Methods: A total of 133 patients with biopsy GS 6 prostate cancer who underwent radical prostatectomy between March 2004 and March 2008 were reviewed. Patients were divided into 4 groups according to the number of positive biopsy core: single positive core (group 1, n=53), 2 (group 2, n=29), 3-5 (group 3, n=39) and 6 or more cores (group 4, n=12). We investigated the value of preoperative variables (age, PSA, Clinical stage, number and laterality of positive core, maximal core length, maximal core percentage) in predicting GS upgrading or upstaging in final pathology.
Results: Among all subjects, 70 (52.6%) were upgraded to GS 7 or higher and 29 (21.8%) were upstaged to pT3 at final pathology. Upgrading rates were 39.6%, 55.2%, 56.4% and 91.7%, and upstaging rates were 13.2%, 13.8%, 28.2% and 58.3% for groups 1, 2, 3 and 4, respectively. The upgrading and upstaging rates were similar among groups 1, 2 and 3, but were significantly higher in group 4 compared to the others. In multivariate analysis, number of positive cores 6 or more was the only factor significantly predictive of upgrading or upstaging following RP. No preoperative variables were observed to predict upgrading or upstaging following RP in patients with 5 or less positive biopsy cores.
Conclusions: Of patients with only one or 2 positive core GS 6 prostate cancers, substantial proportion of cancers upgraded or upstaged in RP specimens, but no predictive factor could be identified. We should keep in mind these when counseling patients.
키워드
Prostatic neoplasms;Biopsy;Prostatectomy
원문 및 링크아웃 정보
등재저널 정보