Comparison of Clinico-Metabolic Characteristics between Calcium Oxalate and Uric Acid Stone Formers
김영원, 하윤석, 김용준, 윤석중, 이상철, 김원재,
소속 상세정보
김영원 ( Kim Young-Won )
Chungbuk National University
하윤석 ( Ha Yun-Sok )
Chungbuk National University
김용준 ( Kim Yong-June )
Chungbuk National University
윤석중 ( Yun Seok-Joong )
Chungbuk National University
이상철 ( Lee Sang-Cheol )
Chungbuk National University
김원재 ( Kim Wun-Jae )
Chungbuk National University
KMID : 0358320090500090897
Abstract
Purpose: Although both intrinsic and environmental factors contribute to urinary stone formation, recent epidemiologic studies have suggested the importance of lifestyle and dietary habit in urolithiasis. The aim of this study was to compare clinical and metabolic characteristics between calcium oxalate (CaOx) and uric acid (UA) stone formers (SF).
Materials and Methods: A database of patient histories and serum and urine chemistries was analyzed for 172 consecutive stone formers [124 pure CaOx SF, 25 mixed (CaOx-UA) SF, and 23 pure UA SF]. We compared the clinical profiles and urinary metabolites among these groups. Urinary CaOx supersaturation was assessed by using the Okawa index.
Results: Compared with pure CaOx SF, SF with an increased UA component were older (p=0.01) and had a higher body mass index (BMI) (p=0.02). However, there were no significant differences in gender, stone episodes, family history, or serum chemistry among the three groups (p＞0.05). In the SF with a greater calcium component, urinary excretion of calcium and CaOx supersaturation were significantly elevated (p＜0.01, respectively). On the contrary, SF with an increased UA component had significantly decreased urine pH (p=0.03).
Conclusions: This study revealed that CaOx stone formation was associated with a young age, hypercalciuria, and high CaOx supersaturation, whereas UA stone formation was associated with high BMI and low urine pH. This study suggests that modification of risk factors in urolithiasis may contribute to preventing stone formation and stone recurrence.
키워드
Urolithiasis;Calcium oxalate;Uric acid;Recurrence
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