기저 전립선특이항원치 및 나이에 따른 전립선특이항원의 측정주기
Prostate-Specific Antigen Test Interval according to Baseline Prostate-Specific Antigen and Age
권문식, 오철영, 유창희, 김선일, 김세중, 김동준, 김영식, 김천일, 김홍섭, 성도환, 송기학, 송윤섭, 양원재, 이동현, 전상현, 조인래, 정병하, 최영득, 홍성준, 임형준, 조진선,
소속 상세정보
권문식 ( Kwon Moon-Sic )
한림대학교 의과대학 비뇨기과학교실
오철영 ( Oh Cheol-Young )
한림대학교 의과대학 비뇨기과학교실
유창희 ( Yoo Chang-Hee )
한림대학교 의과대학 비뇨기과학교실
김선일 ( Kim Sun-Il )
아주대학교 의과대학 비뇨기과학교실
김세중 ( Kim Se-Joong )
아주대학교 의과대학 비뇨기과학교실
김동준 ( Kim Dong-Jun )
관동대학교 의과대학 비뇨기과학교실
김영식 ( Kim Young-Sig )
국민건강보험공단 일산병원 비뇨기과
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
김홍섭 ( Kim Hong-Sup )
건국대학교 의과대학 비뇨기과학교실
성도환 ( Seong Do-Hwan )
인하대학교 의과대학 비뇨기과학교실
송기학 ( Song Ki-Hak )
충남대학교 의과대학 비뇨기과학교실
송윤섭 ( Song Yun-Seob )
순천향대학교 의과대학 비뇨기과학교실
양원재 ( Yang Won-Jae )
순천향대학교 의과대학 비뇨기과학교실
이동현 ( Lee Dong-Hyun )
이화여자대학교 의과대학 비뇨기과학교실
전상현 ( Cheon Sang-Hyeon )
울산대학교 의과대학 비뇨기과학교실
조인래 ( Cho In-Rae )
인제대학교 의과대학 비뇨기과학교실
정병하 ( Chung Byung-Ha )
연세대학교 의과대학 비뇨기과학교실
최영득 ( Choi Young-Deuk )
연세대학교 의과대학 비뇨기과학교실
홍성준 ( Hong Sung-Joon )
연세대학교 의과대학 비뇨기과학교실
임형준 ( Im Hyoung-June )
한림대학교 의과대학 산업의학교실
조진선 ( Cho Jin-Seon )
한림대학교 의과대학 비뇨기과학교실
KMID : 0358320090500111059
Abstract
Purpose: The optimal interval at which to repeat prostate-specific antigen (PSA) measurement is controversial. We evaluated the probability of the serum PSA value increasing above specific cutoff values (4.0 ng/ml, 3.0 ng/ml, and 2.5 ng/ml) on annual follow-up visits in men with a lower baseline PSA than each cutoff value.
Materials and Methods : Between 2002 and 2006, a total of 14,459 men aged 40 to 79 years who underwent serum PSA determinations at least twice during health examinations at 11 medical centers were enrolled in this study. To reduce probable bias, we excluded men with pyuria, those with a baseline or follow-up PSA level of 10.0 ng/ml or more, and those with a history of medication with 5 alpha-reductase inhibitors. Serum PSA underwent logarithmic conversion to work out the normal distribution. The cumulative rate of freedom from increase in PSA above 4.0 ng/ml, 3.0 ng/ml, and 2.5 ng/ml was estimated with the Kaplan-Meier method according to baseline PSA range and age. The significance level was 1%.
Results: The rate of increase in PSA was lower in men who had a baseline PSA value in the low range and whose age was in the 40s or 50s. However, the cumulative rate of freedom from increase in PSA decreased as the PSA cutoff value was lowered. The optimal screening interval for men in their 40s and 50s whose baseline serum PSA level was 1.0 ng/ml or lower was 3 years when the significance level for PSA rising above 4.0 ng/ml was 1%. It was 2 years and 1 year, respectively, when the cutoff value was lowered to 3.0 ng/ml or 2.5 ng/ml. An annual PSA screening interval was recommended in men older than their 60s.
Conclusions: The PSA test interval should be individualized according to baseline PSA, age, and PSA cutoff value.
키워드
Prostate-specific antigen;Age groups
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