Twist and Shout: A Clinical and Experimental Review of Testicular Torsion
Riyad T. Ellati, Parviz K. Kavoussi, Terry T. Turner, Jeffrey J. Lysiak,
소속 상세정보
( Riyad T. Ellati )
University of Virginia Health System Department of Urology
( Parviz K. Kavoussi )
University of Virginia Health System Department of Urology
( Terry T. Turner )
University of Virginia Health System Department of Urology
( Jeffrey J. Lysiak )
University of Virginia Health System Department of Urology
KMID : 0358320090500121159
Abstract
Purpose: This review addresses different aspects of testicular torsion from the clinical perspective as well as the basic cellular and molecular events responsible for the post-torsion testicular changes and pathology, including tissue ischemia-reperfusion injury.
Materials and Methods: A review of all published literature on testicular torsion was performed by use of two search engines.
Results: Testicular torsion, or more correctly termed torsion of the spermatic cord, is a surgical emergency in order to salvage the testis. Its incidence is approximately 1 in 4,000 per annum. Testicular torsion must be treated promptly to avoid loss of the ipsilateral testis; however, even with torsion repair and gross testicular salvage, significant injury may still occur.
Conclusions: The cellular and molecular mechanisms leading to ischemia- reperfusion injury are incompletely understood, and adjuncts to surgical treatment have received little attention. Understanding the cellular and molecular effects is important because 25% of males with a history of torsion may experience adult infertility. This review emphasizes current knowledge of basic science results and clinical outcomes of testicular torsion.
키워드
Testis;Testicular torsion;Ischemia;Reperfusion;Apoptosis
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