전이성 전립선암으로 인해 발생한 척수압박 환자의 임상적 특성 분석
Analysis of the Clinical Features of Patients with Metastatic Spinal Cord Compression Caused by Prostate Cancer
홍성우, 유달산, 홍준혁, 김청수, 안한종, 정인갑,
소속 상세정보
홍성우 ( Hong Sung-Woo )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
유달산 ( You Dal-San )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
홍준혁 ( Hong Jun-Hyuk )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
김청수 ( Kim Choung-Soo )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
안한종 ( Ahn Han-Jong )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
정인갑 ( Jeong In-Gab )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
KMID : 0358320090500121174
Abstract
Purpose: The purpose of this study was to investigate the clinical presentation and outcomes of metastatic spinal cord compression (MSCC) caused by prostate cancer (PCa) and to determine the prognostic factors for relieving the symptoms of MSCC.
Materials and Methods: A total of 52 patients (47 who underwent radiotherapy and 5 who underwent surgery) treated between 1989 and 2007 were included. We investigated potential prognostic factors for the improvement of symptoms caused by MSCC. Multivariate Cox proportional hazards regression was used to determine the independent significant factors for disease-specific survival (DSS).
Results: Twenty-four (51.1%) of 47 patients and 3 (60%) of 5 patients showed symptom improvement after radiotherapy or surgery, respectively. The number of involved vertebrae (1 or 2) as well as ambulatory and Eastern Cooperative Oncology Group performance status (ECOG PS, 1 or 2) before radiotherapy or surgery were significant predictors of improvement of symptoms caused by MSCC (p=0.024, p=0.001, and p=0.001, respectively). In the multivariate analysis, hemoglobin (≥11.1), the number of involved vertebrae (1 or 2), and ECOG PS (1 or 2) remained significant predictors (p=0.021, p=0.033, and p=0.034, respectively). On the Kaplan-Meier curve, however, only ECOG PS (1 or 2) was a significant factor predicting DSS (p=0.014).
Conclusions: In our study, improvement of symptoms after treatment was observed in half of the MSCC patients; however, there were no factors predicting symptom improvement other than the number of involved vertebrae and the patients’ ambulatory and performance status at the time of treatment. Patients with ECOG PS 1 or 2 may therefore be expected to have good DSS after radiotherapy or surgery.
키워드
Prostatic neoplasms;Spinal cord compression;Radiotherapy;Survival rate
원문 및 링크아웃 정보
등재저널 정보