mRNA Expression of S100A8 as a Prognostic Marker for Progression of Non-Muscle-Invasive Bladder Cancer
하윤석, 김용준, 이상철, 김원재, 윤석중, 김민주, 윤형윤, 강호원,
소속 상세정보
하윤석 ( Ha Yun-Sok )
Chungbuk National University
김용준 ( Kim Yong-June )
Chungbuk National University
이상철 ( Lee Sang-Cheol )
Chungbuk National University
김원재 ( Kim Wun-Jae )
Chungbuk National University
윤석중 ( Yun Seok-Joong )
Chungbuk National University
김민주 ( Kim Min-Ju )
Chungbuk National University
윤형윤 ( Yoon Hyung-Yoon )
Chungbuk National University
강호원 ( Kang Ho-Won )
Chungbuk National University
KMID : 0358320100510010015
Abstract
Purpose: S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. Altered expression of this protein is associated with various diseases and cancers. The present study aimed to evaluate whether S100A8 has prognostic value for non-muscle-invasive bladder cancer (NMIBC).
Materials and Methods: A total of 103 primary NMIBC samples obtained by transurethral resection were evaluated. mRNA levels were examined by real-time reverse transcriptase polymerase chain reaction (RT-PCR) analysis. The results were compared with clinico-pathological parameters. The Kaplan-Meier method was applied to plot the curves for progression-free survival. The multivariate Cox regression model was used to identify the independent prognostic factors for progression.
Results: mRNA expression levels of S100A8 were significantly related to the progression of NMIBC. Kaplan-Meier estimates demonstrated significant differences in tumor progression according to the level of S100A8 expression (log-rank test, p＜0.001). The multivariate Cox regression model revealed that the S100A8 mRNA expression level (hazard ratio: 12.538; 95% confidence interval: 2.245-70.023, p=0.004) was an independent predictor for disease progression of NMIBC.
Conclusions: Expression levels of S100A8 might be a useful prognostic marker for disease progression of NMIBC.
키워드
Urinary bladder neoplasms;S100A8 protein;Polymerase chain reaction;Biological tumor markers
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