Alteration of Antithrombin III and D-dimer Levels in Clinically Localized Prostate Cancer
홍성규, 정성진, 변석수, 이상은, 박주현, 박홍주, 윤철용, 고동우, 김인성, 두승환, 이원기, 김대성,
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홍성규 ( Hong Sung-Kyu )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
정성진 ( Jeong Seong-Jin )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
변석수 ( Byun Seok-Soo )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
이상은 ( Lee Sang-Eun )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
박주현 ( Park Ju-Hyun )
서울대학교 의과대학 비뇨기과학교실
박홍주 ( Park Hong-zoo )
분당서울대학교병원 비뇨기과
윤철용 ( Yoon Cheol-Yong )
분당서울대학교병원 비뇨기과
고동우 ( Ko Dong-Woo )
서울대학교 의과대학 비뇨기과학교실
김인성 ( Kim In-Sung )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
두승환 ( Doo Seung-Hwan )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
이원기 ( Lee Won-Ki )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
김대성 ( Kim Dae-Sung )
서울대학교 의과대학 분당서울대학교병원 비뇨기과학교실
KMID : 0358320100510010025
Abstract
Purpose: We performed a comparative analysis of the plasma levels of antithrombin (AT) III, plasminogen, fibrinogen, and D-dimer among patients with and without clinically localized prostate cancer to investigate the clinical significance of the coagulation profile in prostate cancer.
Materials and Methods: A prospective study was performed in which plasma levels of AT III, plasminogen, fibrinogen, and D-dimer were assessed in patients before they underwent prostate biopsy. According to the results of the biopsy, the patients were categorized into the cancer group or the control group. Levels of the four coagulation factors were then compared between the cancer and control groups. Also, levels of the four coagulation factors were correlated with tumor stage and grade in the cancer group.
Results: The cancer group had significantly lower levels of AT III activity and higher plasma D-dimer levels than did the control group (p=0.007 and p=0.018, respectively). Within the cancer group, no significant differences were observed in the levels of AT III, plasminogen, fibrinogen, or D-dimer between those with a pathological Gleason score of ≥7 and otherwise. Regarding pathologic stage of prostate cancer, the subjects with organ-confined disease and those with extraprostatic extension of a tumor demonstrated no significant differences in the preoperative levels of the four coagulation factors analyzed.
Conclusions: Our results suggest that plasma levels of AT III and D-dimer are altered in patients with prostate cancer. Further study is needed to elucidate the underlying mechanism and clinical significances of such a phenomenon among patients with clinically localized prostate cancer.
키워드
Prostatic neoplasms;Blood coagulation tests
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