Comparison of Metabolic Risk Factors in Urolithiasis Patients according to Family History
박철, 김용준, 이상철, 김원재, 하윤석, 윤석중,
소속 상세정보
박철 ( Park Cheol )
Chungbuk National University
김용준 ( Kim Yong-June )
Chungbuk National University
이상철 ( Lee Sang-Cheol )
Chungbuk National University
김원재 ( Kim Wun-Jae )
Chungbuk National University
하윤석 ( Ha Yun-Sok )
Chungbuk National University
윤석중 ( Yun Seok-Joong )
Chungbuk National University
KMID : 0358320100510010050
Abstract
Purpose: Urolithiasis develops more frequently in patients with a family history (FHx). However, little is known about risk factors in stone formers with a FHx. The aim of this study was to examine the clinico-metabolic characteristics of urinary stone formers according to FHx.
Materials and Methods: A database of 1,068 stone formers who underwent a complete metabolic evaluation was reviewed. The patients were divided into two groups on the basis of the presence of a FHx. Clinical factors and metabolic parameters were compared between the two groups.
Results: There were no significant differences in clinical characteristics, such as gender, age, body mass index, stone episodes, or multiple stones, between the two groups (p＞0.05, respectively). Compared with stone formers without a FHx, however, serum calcium concentrations were more elevated in stone formers with a FHx. Also, the urinary excretion of calcium was higher in stone formers with a FHx than in those without a FHx. Other urinary metabolites showed no significant differences between the two groups (p＞0.05, respectively).
Conclusions: Our study revealed that stone formers with a FHx had increased urinary calcium excretion as well as elevated concentrations of serum calcium. This finding suggests that urolithiasis in stone formers with a FHx may be associated with calcium metabolic abnormalities.
키워드
Calcium;Family characteristics;Urolithiasis
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