Effect of Stress on the Expression of Rho-Kinase and Collagen in Rat Bladder Tissue
윤하나, 이동현, 전계민, 윤현석, 유재영,
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윤하나 ( Yoon Ha-Na )
이화여자대학교 의과대학 비뇨기과학교실
이동현 ( Lee Dong-Hyun )
이화여자대학교 의과대학 비뇨기과학교실
전계민 ( Chun Kye-Min )
이화여자대학교 의과대학 비뇨기과학교실
윤현석 ( Yoon Hyun-Suk )
이화여자대학교 의학전문대학원 비뇨기과학교실
유재영 ( Yoo Jae-Yeong )
이화여자대학교 의과대학 비뇨기과학교실
KMID : 0358320100510020132
Abstract
Purpose: We examined the effect of stress on the pathophysiology of bladder stability in terms of enzyme levels, Rho-kinase, and bladder relaxation.
Materials and Methods : A total of 48 female Sprague-Dawley rats were studied in scheduled stress environments for 7, 14, and 28 days; 24 rats were in the control group and 24 rats were in the test (stressed) group.
Results: Estrogen decreased significantly whereas testosterone and dopamine increased significantly in the stress group (p＜0.05). Rho-kinase was significantly increased in the rats exposed to stress stimuli for 14 days (p＜0.05). Collagen types I and III in the bladder tissue were significantly higher in rats exposed to stress for 14 days and 28 days (collagen type I in the 14-day group, p＜0.01; collagen type I in the 28-day group, p＜0.05; collagen type III in the 14-day and 28-day groups, p＜0.05). Voiding frequency increased significantly as the duration of stress exposure was prolonged, in addition to a significant decrease in volume per voiding (p＜0.05).
Conclusions: The changes observed in micturition pattern, factors that contribute to smooth muscle contraction, and relaxation in the female rat bladder support the hypothesis that stress affects bladder stability.
키워드
Physiology;Urinary bladder
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