Tamsulosin versus Alfuzosin in the Treatment of Patients with Distal Ureteral Stones: Prospective, Randomized, Comparative Study
Abul-fotouh Abdel-maguid Ahmed, Abul-yazid Saad Al-sayed,
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( Abul-fotouh Abdel-maguid Ahmed )
Kingdom of Saudi Arabia Ghodran Hospital Departments of Urology
( Abul-yazid Saad Al-sayed )
Kingdom of Saudi Arabia Ghodran Hospital Departments of Emergency
KMID : 0358320100510030193
Abstract
Purpose: We evaluated and compared the efficacy of tamsulosin and alfuzosin in the medical treatment of symptomatic, uncomplicated distal ureteral stones.
Materials and Methods: A total of 87 patients with distal ureteral stones of ¡Â10 mm were randomly divided into 3 groups. Group I patients (n=29) received 0.4 mg tamsulosin daily, group II patients (n=30) received 10 mg alfuzosin daily, and group III patients (n=28) were not given tamsulosin or alfuzosin. Patients in all groups received Diclofenac sodium regularly for 1 week and then on demand. Follow-up was done on a weekly basis for 30 days.
Results: The mean stone size was comparable in the 3 groups (4.97¡¾2.24, 5.47¡¾2.13, and 5.39¡¾1.81 mm, respectively). The stone expulsion rate was 86.2%, 76.6%, and 50% in groups I, II, and III, respectively. The difference in groups I and II with respect to group III was significant (p=0.0028 and 0.035). The mean expulsion time for groups I to III was 7.52¡¾7.06, 8.26¡¾7.34, and 13.90¡¾6.99 days, respectively. The expulsion time was significantly shorter in groups I and II than in group III (p=0.0097 and 0.026). Patients taking tamsulosin and alfuzosin had fewer pain attacks than did group III patients (1.24¡¾0.57 vs. 1.43¡¾0.67 vs. 1.75¡¾1.17). Only 3 cases of drug side effects, 2 in group I and 1 in group II, were recorded.
Conclusions: The use of tamsulosin or alfuzosin for the medical treatment of lower ureteric stones proved to be safe and effective. Moreover, tamsulosin did not have any significant benefits over alfuzosin.
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Urinary calculi;Ureter;Alfuzosin;Tamsulosin
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