Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer
서경원, 권영기, 김병훈, 김천일, 장혁수, 최미선, 박철희,
소속 상세정보
서경원 ( Seo Kyung-Won )
계명대학교 의과대학 비뇨기과학교실
권영기 ( Kwon Young-Kee )
계명대학교 의과대학 비뇨기과학교실
김병훈 ( Kim Byung-Hoon )
계명대학교 의과대학 비뇨기과학교실
김천일 ( Kim Chun-Il )
계명대학교 의과대학 비뇨기과학교실
장혁수 ( Chang Hyuk-Soo )
계명대학교 의과대학 비뇨기과학교실
최미선 ( Choe Mi-Sun )
계명대학교 의과대학 병리학교실
박철희 ( Park Choal-Hee )
계명대학교 의과대학 비뇨기과학교실
KMID : 0358320100510040239
Abstract
Purpose: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer.
Materials and Methods: The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer.
Results: In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin- 5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis.
Conclusions: The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer.
키워드
Claudin 1;CLDN5 protein;Prostate-specific antigen;Prostatic neoplasms
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