Changes in Aquaporin 1 Expression in Rat Urinary Bladder after Partial Bladder Outlet Obstruction: Preliminary Report
김선옥, 송승희, Ahn Ku-Youn, 권동득, 박광성, 류수방,
소속 상세정보
김선옥 ( Kim Sun-Ouck )
전남대학교 의과대학 비뇨기과학교실
송승희 ( Song Seung-Hee )
전남대학교 의과대학 비뇨기과학교실
( Ahn Ku-Youn )
전남대학교 의과대학 해부학교실
권동득 ( Kwon Dong-Deuk )
전남대학교 의과대학 비뇨기과학교실
박광성 ( Park Kwang-Sung )
전남대학교 의과대학 비뇨기과학교실
류수방 ( Ryu Soo-Bang )
전남대학교 의과대학 비뇨기과학교실
KMID : 0358320100510040281
Abstract
Purpose: Aquaporins (AQPs) are membrane proteins that facilitate water movement across biological membranes. AQPs are also called water channels, and they have recently been reported to be expressed in rat and human urothelium. The purposes of this study were to investigate the effect of bladder outlet obstruction (BOO) on the rat urothelium and AQP1 expression in rat urothelium.
Materials and Methods: Female Sprague-Dawley rats (230-240 g each, n=20) were divided into 2 groups: the sham group (the Con group, n=10) and the partial BOO group (the BOO group, n=10). The BOO group underwent a partial BOO. The expression and cellular localization of AQP1 were determined by performing Western blotting and immunohistochemistry on the rat urinary bladder.
Results: AQP1 immunoreactivity in both the control and the BOO groups was localized in the capillaries, arterioles, and venules of the lamina propria of the urinary bladder. The protein expression of AQP1 was significantly increased in the BOO group.
Conclusions: This study showed that BOO causes a significant increase in the expression of AQP1. This may imply that AQP1 has a functional role in the detrusor instability that occurs in association with BOO.
키워드
Aquaporins;Urinary bladder;Urethral obstruction;Rats
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