Significance of S100A2 and S100A4 Expression in the Progression of Prostate Adenocarcinoma
권용욱, 명순철, 김영선, 김미경, 김태형, 김경도, 장인호,
소속 상세정보
권용욱 ( Kwon Yong-Wook )
중앙대학교 의과대학 비뇨기과학교실
명순철 ( Myung Soon-Chul )
중앙대학교 의과대학 비뇨기과학교실
김영선 ( Kim Young-Sun )
중앙대학교 의과대학 비뇨기과학교실
김미경 ( Kim Mi-Kyung )
중앙대학교 의과대학 병리학교실
김태형 ( Kim Tae-Hyoung )
중앙대학교 의과대학 비뇨기과학교실
김경도 ( Kim Kyung-Do )
중앙대학교 의과대학 비뇨기과학교실
장인호 ( Chang In-Ho )
중앙대학교 의과대학 비뇨기과학교실
KMID : 0358320100510070456
Abstract
Purpose: The aim of this study was to investigate the expression pattern of calcium-binding proteins S100A2 and S100A4. We also sought to determine the prognostic value of these markers for patients with prostate adenocarcinoma.
Materials and Methods: Immunohistochemical staining was performed to detect S100A2 and S100A4 expression in 26 tissue samples obtained during transurethral resection from patients with benign prostatic hyperplasia (BPH) and in 67 tissue samples obtained during prostate biopsy and radical prostatectomy from patients with prostate carcinoma. The immunoreactivity of these proteins was stratified on a scale of 0 to 3 and was correlated with the pathologic features of prostate adenocarcinoma.
Results: High expression of S100A2 was observed in the tissue of patients with BPH, whereas low or no expression was observed in prostate cancer (CaP) cells. The protein level of S100A4 was significantly higher in CaP than in BPH cells. The higher level of S100A4 observed in CaP tissue correlated with increasing tumor grade.
Conclusions: Decreased expression of S100A2 and increased expression of S100A4 may be important in the progression of CaP. This finding could aid in identifying aggressive CaP. The simultaneous analysis of S100A2 and S100A4 expression in prostate tissues may be a useful prognostic marker for CaP.
키워드
Prostatic hyperplasia;Prostatic neoplasms;S100A2 protein;human;S100A4 protein;human
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