Is Activating Transcription Factor 3 Up-Regulated in Patients with Hypospadias?
Gurbuz Cenk, Demir Selamettin, Zemheri Ebru, Canat Lutfi, Kilic Mert, Caskurlu Turhan,
소속 상세정보
( Gurbuz Cenk )
Turkey Istanbul Goztepe Training Hospital Departments of 2nd Urology
( Demir Selamettin )
Turkey Istanbul Goztepe Training Hospital Departments of 2nd Urology
( Zemheri Ebru )
Turkey Istanbul Goztepe Training Hospital Departments of Pathology
( Canat Lutfi )
Turkey Istanbul Goztepe Training Hospital Departments of 2nd Urology
( Kilic Mert )
Turkey Istanbul Goztepe Training Hospital Departments of 2nd Urology
( Caskurlu Turhan )
Turkey Istanbul Goztepe Training Hospital Departments of 2nd Urology
KMID : 0358320100510080561
Abstract
Purpose: Even though hypospadias is one of the most common congenital anomalies, the cause of hypospadias is largely unknown. With regard to molecular biology and microarray technology, it appears that hypospadias is potentially related to disrupted gene expression. Genomic analysis of hypospadiac tissue indicated a potential role for activating transcription factor 3 (ATF3) in the development of this anomaly. This study prospectively examined the expression of ATF3 in tissues from 20 children with hypospadias compared with 26 normal penile skin tissue samples from elective circumcision.
Materials and Methods: Prepucial tissue was obtained from children who underwent repair of hypospadias for comparison with tissue samples from children who underwent elective circumcision. Skin specimens were evaluated for the expression of ATF3 protein by immunohistochemical staining.
Results: Immunohistochemical staining for ATF3 in samples from children who underwent repair of hypospadias was significantly greater than in samples from children who underwent elective circumcision (80% vs. 11%, respectively; p<0.05).
Conclusions: Our results indicate that ATF3 is up-regulated in the penile skin tissue of boys with hypospadias, which suggests a role for this transcription factor in the development of this abnormality.
키워드
Activating transcription factor 3;Estrogens;Genetics;Hypospadias;Urogenital abnormalities
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