Prevalence and Treatment Efficacy of Genitourinary Mycoplasmas in Women with Overactive Bladder Symptoms
이영숙, 김지윤, 김준철, 박원희, 주명수, 이규성,
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이영숙 ( Lee Young-Suk )
성균관대학교 의과대학 비뇨기과학교실
김지윤 ( Kim Ji-Yoon )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
김준철 ( Kim Joon-Chul )
가톨릭대학교 의과대학 강남성모병원 비뇨기과학교실
박원희 ( Park Won-Hee )
인하대학교 의과대학 비뇨기과학교실
주명수 ( Choo Myung-Soo )
울산대학교 의과대학 서울아산병원 비뇨기과학교실
이규성 ( Lee Kyu-Sung )
성균관대학교 의과대학 비뇨기과학교실
KMID : 0358320100510090625
Abstract
PurposeTo evaluate the incidence of genitourinary mycoplasmas and the efficacy of antibiotics in women with overactive bladder (OAB) symptoms.
Materials and MethodsWomen with OAB symptoms (micturition ≥8/24 hours and urgency ≥1/24 hours) for ≥3 months were screened for Mycoplasma hominis (M. hominis), Ureaplasma urealyticum (U. urealyticum), and Chlamydia trachomatis (C. trachomatis). Specimens from urethral and cervical vaginal swabs were examined for M. hominis and U. urealyticum by using the Mycoplasma IST2 kit and for C. trachomatis by using PCR. Women with positive results were treated with a 1 g dose of azithromycin. Persistent infection was treated with doxycycline. Changes in a 3-day bladder diary, Patient Perception of Bladder Condition (PPBC), and International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) were evaluated 4 weeks after negative conversion. Patient satisfaction was assessed.
ResultsOf 84 women screened, 42.8% were positive (U. urealyticum, 40.5%; M. hominis, 7.1%; C. trachomatis, 3.6%; two organisms, 8.3%). After treatment, 82.7% obtained negative conversion, and their median number of micturition episodes decreased from 10.6/24 hours to 8.1/24 hours (p=0.002). PPBC and domain scores of the ICIQ-FLUTS (filling and quality of life) significantly improved. About 87.5% women with negative conversion were satisfied with the treatment.
ConclusionsConsidering diagnostic tests and treatment for genitourinary mycoplasmas might be beneficial before invasive workup or treatment in women with OAB symptoms.
키워드
Chlamydia trachomatis;Mycoplasma hominis;Overactive urinary bladder;Ureaplasma urealyticum
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