Efficacy and Safety of Tadalafil 5 mg Administered Once Daily in Korean Men with Erectile Dysfunction: A Prospective, Multicenter Study
강동혁, 이주용, 박성열, 문홍상, 정태융, 유탁근, 최홍용, 박해영, Lee Tchun Yong, 이승욱,
소속 상세정보
강동혁 ( Kang Dong-Hyuk )
한양대학교 의과대학 비뇨기과학교실
이주용 ( Lee Joo-Yong )
한양대학교 의과대학 비뇨기과학교실
박성열 ( Park Sung-Yul )
한양대학교 의과대학 비뇨기과학교실
문홍상 ( Moon Hong-Sang )
한양대학교 의과대학 비뇨기과학교실
정태융 ( Jeong Tae-Yoong )
관동대학교 의과대학 비뇨기과학교실
유탁근 ( Yoo Tag-Keun )
을지대학교 의과대학 을지병원 비뇨기과
최홍용 ( Choi Hong-Yong )
한양대학교 의과대학 비뇨기과학교실
박해영 ( Park Hae-Young )
한양대학교 의과대학 비뇨기과학교실
( Lee Tchun Yong )
한양대학교 의과대학 비뇨기과학교실
이승욱 ( Lee Seung-Wook )
을지대학교 의과대학 을지병원 비뇨기과학교실
KMID : 0358320100510090647
Abstract
PurposeThe aim of this study was to evaluate the efficacy of a daily dose of tadalafil 5 mg as well as its safety for the cardiovascular system in men with erectile dysfunction.
Materials and MethodsThis study included a total of 162 men who were administered a daily dose of tadalafil 5 mg between April and December of 2009. A total of 127 men completed the 8-week clinical trial. The International Index of Erectile Function (IIEF)-5, blood pressure, and heart rate were measured before treatment with tadalafil (V1) and 4 (V2) and 8 weeks (V3) after treatment with tadalafil. Adverse effects were assessed at V1, V2, and V3. In cases in which the International Prostate Symptom Score (IPSS) was ≥8 at V1, maximal flow rate (Qmax) and postvoid residual volume (PVR) were measured.
ResultsThe IIEF-5 values were 11.25±3.18, 14.56±3.79, and 16.91±3.56 at V1, V2, and V3, respectively, with significant improvement (V1 vs. V2, p<0.001; V1 vs. V3, p<0.001). The IPSS values were 10.59±5.56, 9.07±6.06, and 8.15±6.10 at V1, V2, and V3, respectively, and the differences were statistically significant (V1 vs. V2, p<0.001; V1 vs. V3, p<0.001). There were no significant differences in blood pressure or heart rate. Adverse effects were observed in 7 men (5.51%) at V2 and in 5 men (3.94%) at V3.
ConclusionsTadalafil 5 mg administered once-a-day may be effective in improving erectile function. Adverse effects on the cardiovascular system may be minimal. In addition, it is believed that this may also be effective in improving voiding symptoms.
키워드
Erectile dysfunction;Safety;Tadalafil;Treatment outcome
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