Effect of Korean Red Ginseng on Testicular Tissue Injury after Torsion and Detorsion
김영호, 김건화, 신주현, Kim Kang-Sup, 임재성,
소속 상세정보
김영호 ( Kim Young-Ho )
충남대학교 의과대학 비뇨기과학교실
김건화 ( Kim Gun-Hwa )
Korea Daejeon Korea Basic Science Institute(KBSI) Department of Life Science
신주현 ( Shin Ju-Hyun )
충남대학교 의과대학 비뇨기과학교실
( Kim Kang-Sup )
충남대학교 의과대학 비뇨기과학교실
임재성 ( Lim Jae-Sung )
충남대학교 의과대학 비뇨기과학교실
KMID : 0358320100510110794
Abstract
Purpose Korean red ginseng (KRG) is a potent antioxidant and a free radical scavenger. This study was designed to determine whether KRG could protect against dysfunction and oxidative stress induced by torsion-detorsion injury in rat testis.
Materials and Methods Six-week-old male Sprague-Dawley rats were randomly divided into four groups: a sham-operated control group (C), a sham-operated and KRG-treated group (K), a 2 hours torsion and detorsion group (T), and a 2 hours torsion and detorsion and KRG-treated group (T+K). We measured testis weight and hormone levels and reactive oxygen species (ROS) from the left renal vein. Superoxide generation was measured on the basis of lucigenin-enhanced chemiluminescence in testis tissue.
Results Testicular weight was significantly higher in the T+K group than in the T group; however, there were no significant differences in hormone levels between the 4 groups. The mean level of ROS and superoxide production was significantly higher in the T group than in the C group, whereas administration of KRG attenuated this increase. Upon histologic evaluation, the T group was found to have cellular disarray, a lack of cellular cohesiveness, degenerative changes in the germinal cells, and less distinct changes in the seminiferous tubules, whereas the T+K group had a germinal epithelial layer that appeared nearly normal.
Conclusions The present study demonstrated that KRG recovered the testis dysfunction in the rat testis by suppressing superoxide production.
키워드
Ginseng; Oxidative stress; Testicular torsion
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