Cyclooxygenase-2 Overexpression in Chronic Inflammation Associated with Benign Prostatic Hyperplasia: Is It Related to Apoptosis and Angiogenesis of Prostate Cancer?
김병훈, 김천일, 장혁수, 최미선, 정혜라, 김덕윤, 박철희,
소속 상세정보
김병훈 ( Kim Byung-Hoon )
Keimyung University School of Medicine Department of Urology
김천일 ( Kim Chun-Il )
Keimyung University School of Medicine Department of Urology
장혁수 ( Chang Hyuk-Soo )
Keimyung University School of Medicine Department of Urology
최미선 ( Choe Mi-Sun )
Keimyung University College of Medicine Department of Pathology
정혜라 ( Jung Hye-Ra )
Keimyung University College of Medicine Department of Pathology
김덕윤 ( Kim Duk-Yoon )
Catholic University of Daegu College of Medicine Department of Urology
박철희 ( Park Choal-Hee )
Keimyung University School of Medicine Department of Urology
KMID : 0358320110520040253
Abstract
Purpose: This study was performed to investigate the relationship between cyclooxygenase-2 (COX-2) expression and apoptosis/angiogenesis in inflammatory and noninflammatory benign prostatic hyperplasia (BPH) and prostate cancer (PC).
Materials and Methods: This study involved 64 BPH and 57 PC patients. The BPH histopathologies were classified by the presence of chronic inflammation as follows: noninflammatory BPH (NI-BPH; n=23) and inflammatory BPH (I-BPH; n=41). The association between the expression of COX-2, expression of Bcl-2, the apoptotic index (AI), expression of vascular endothelial growth factor (VEGF), and microvascular density (MVD) in the prostate was investigated.
Results: An overexpression of COX-2, Bcl-2, and VEGF was observed in cases of PC compared with cases of BPH. In PC, the AI was lower and MVD was higher than in BPH. In NI-BPH, I-BPH, and PC, the overexpression of COX-2, Bcl-2, and VEGF gradually increased. The AI was high in I-BPH, but did not differ significantly between the NI-BPH and I-BPH groups or between the NI-BPH and PC groups. MVD was significantly high in PC, but no significant difference was found between NI-BPH and I-BPH. A significant correlation was shown between the overexpression of COX-2 and Bcl-2, and COX-2 and VEGF. However, the AI was not correlated with the overexpression of COX-2 or Bcl-2. MVD was correlated with the overexpression of COX-2 and VEGF.
Conclusions: COX-2 overexpression in PC is correlated with a decrease in apoptosis and an increase in angiogenesis. Chronic inflammation in BPH causes an overexpression of COX-2, which induces the increased expression of Bcl-2 and VEGF. It is likely that chronic inflammation plays a role in the intermediate step of carcinogenesis in the prostate.
키워드
Angiogenesis-inducing agents; Apoptosis; Cyclooxygenase 2; Prostatic hyperplasia; Prostatic neoplasms
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