Long-Term Effect of Loxoprofen Sodium on Nocturia in Patients with Benign Prostatic Hyperplasia
신홍일, 김병훈, 장혁수, 박철희, 김천일,
소속 상세정보
신홍일 ( Shin Hong-Il )
Keimyung University School of Medicine Department of Urology
김병훈 ( Kim Byung-Hoon )
Keimyung University School of Medicine Department of Urology
장혁수 ( Chang Hyuk-Soo )
Keimyung University School of Medicine Department of Urology
박철희 ( Park Choal-Hee )
Keimyung University School of Medicine Department of Urology
김천일 ( Kim Chun-Il )
Keimyung University School of Medicine Department of Urology
KMID : 0358320110520040265
Abstract
Purpose: We evaluated the long-term effects of loxoprofen on nocturia in patients with benign prostatic hyperplasia (BPH).
Materials and Methods: Between January 2006 and December 2008, 40 BPH patients with 2 or more episodes of nocturia received an alpha-blocker, 5-alpha reductase inhibitor, and a single dose of 60 mg of loxoprofen at night before sleep for 12 months (Group I). During the same period, 38 BPH patients selected as the control group received an alpha-blocker and 5-alpha reductase inhibitor (Group II). Patients were reevaluated after 3, 6, and 12 months of treatment by the number of nocturia episodes and side effects.
Results: After 3 months of treatment, the number of nocturia episodes decreased significantly compared with baseline in both group I and group II (1.9±0.7, 2.1±0.7, respectively, p<0.05). The degree of decrease in nocturia was significantly different between the groups (-1.5±0.9, -1.1±0.9, respectively, p=0.034). After 6 and 12 months, the number of nocturia episodes decreased significantly compared with baseline in both group I and group II (p<0.05), but the degree of decrease was not significantly different between the groups (p>0.05). After 6 and 12 months of treatment in group I, treatment-emergent adverse events, including 5 cases of gastric discomfort (12.5%), 3 cases of leg edema (7.5%), and 1 case of decreased urine volume (2.5%), occurred in 9 of the 40 (22.5%) patients.
Conclusions: Loxoprofen can be an effective treatment for patients with nocturia secondary to BPH in the short term. Long-term use of loxoprofen is not recommended because of the side effects.
키워드
Loxoprofen; Nocturia; Prostatic hyperplasia
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