Effect of Desmopressin with Anticholinergics in Female Patients with Overactive Bladder
Han Young-Kook, 이원기, 이성호, 양대열, 김하영,
소속 상세정보
( Han Young-Kook )
Hallym University College of Medicine Department of Urology
이원기 ( Lee Won-Ki )
Hallym University College of Medicine Department of Urology
이성호 ( Lee Seong-Ho )
Hallym University College of Medicine Department of Urology
양대열 ( Yang Dae-Yul )
Hallym University College of Medicine Department of Urology
김하영 ( Kim Ha-Young )
Hallym University College of Medicine Department of Urology
KMID : 0358320110520060396
Abstract
Purpose: The aim of this study was to evaluate the effect of desmopressin combined with anticholinergics on daytime frequency and urgency in female patients with overactive bladder (OAB).
Materials and Methods: We included 68 female patients with OAB. Patients were randomly assigned to receive 5 mg of solifenacin (group I) or 5 mg of solifenacin and 0.2 mg of desmopressin (group II) for 2 weeks. A pre/post-treatment 3-day voiding diary and the Urinary Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) were used to assess changes in voiding symptoms and quality of life (QoL); results were compared between the two groups.
Results: Groups I and II included 31 and 37 patients, respectively. Time to first void was 12 min later in group II (105 min vs. 117 min), but this difference was not statistically significant. However, time to the second and third voids (203 min vs. 255 min, 312 min vs. 368 min) and the first urgency episode (212 min vs. 255 min) were significantly longer in group II. Compared with group I, patients in group II showed significant improvement in QoL scores. When improvement after treatment was defined as increase in time to first void of greater than 10% after 2 weeks of treatment, desmopressin with anticholinergics was more effective in patients over the age of 65 years and with more than 150 ml of voided volume.
Conclusions: Desmopressin combined with anticholinergics was more effective than anticholinergics only in the treatment of female patients with OAB.
키워드
Anticholinergics; Desmopressin; Overactive bladder
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