Correlation between Chemokine Receptor CXCR4 Expression and Prognostic Factors in Patients with Prostate Cancer
정석진, 김천일, 박철희, Chang Hyuck-Soo, 김병훈, 최미선, Jung Hyea-Ra,
소속 상세정보
정석진 ( Jung Seok-Jin )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
김천일 ( Kim Chun-Il )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
박철희 ( Park Choal-Hee )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
( Chang Hyuck-Soo )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
김병훈 ( Kim Byung-Hoon )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
최미선 ( Choi Mi-Sun )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
( Jung Hyea-Ra )
Keimyung University School of Medicine Dongsan Medical Center Department of Urology
KMID : 0358320110520090607
Abstract
Purpose: We evaluated the correlation between the expression of CXCR4 and prognostic factors in patients with prostate cancer.
Materials and Methods : A total of 57 patients who had undergone surgery for prostate cancer were enrolled. Specimens were obtained before any treatment and were stained with antihuman CXCR4 antibody. The intensity of staining was graded as low or high. The age, pretreatment prostate-specific antigen (PSA) level, Gleason score, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of CXCR4 in patients with prostate cancer.
Results: Local recurrence was higher in the group with high expression, in 11 of 36 cases (30.6%), than in the group with low expression, in 1 of 21 cases (4.8%), with statistical significance (p=0.040). Distant metastasis was also associated with expression, occurring in 10 of 36 cases (27.8%) in the group with high expression and in 1 of 21 cases (4.8%) in the group with low expression (p=0.041). In the logistic regression test, CXCR4 expression was the only factor in determining local recurrence (p=0.016) and distant metastasis (0.022). Furthermore, the group with high CXCR4 expression showed significantly longer cancer-specific survival than did the low expression group (p=0.041). CXCR4 showed no association with age (p=0.881), pretreatment PSA level (p=0.584), Gleason score (p=0.640), T stage (p=0.967), or biochemical recurrence (p=0.081).
Conclusions: The high expression of CXCR4 was associated with local recurrence and distant metastasis. CXCR4 expression was shown to be a useful prognostic factor for patients with prostate cancer.
키워드
CXCR4;Receptor;Prognosis;Prostate neoplasms
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