Effect of Prostate Biopsy Hemorrhage on MRDW and MRS Imaging
이종연, 장인호, 문영태, 김경도, 명순철, 김태형, 이종범,
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이종연 ( Lee Jong-Yeon )
Chung-Ang University College of Medicine Department of Urology
장인호 ( Chang In-Ho )
Chung-Ang University College of Medicine Department of Urology
문영태 ( Moon Young-Tae )
Chung-Ang University College of Medicine Department of Urology
김경도 ( Kim Kyung-Do )
Chung-Ang University College of Medicine Department of Urology
명순철 ( Myung Soon-Chul )
Chung-Ang University College of Medicine Department of Urology
김태형 ( Kim Tae-Hyoung )
Chung-Ang University College of Medicine Department of Urology
이종범 ( Lee Jong-Beum )
Chung-Ang University College of Medicine Department of Radiology
KMID : 0358320110520100674
Abstract
Purpose:To retrospectively evaluate the effect of post-prostate-biopsy hemorrhage on the interpretation of magnetic resonance diffusion-weighted (MRDW) and magnetic resonance spectroscopic (MRS) imaging in the detection of prostate cancer. We also investigated the optimal timing for magnetic resonance examination after prostate biopsy.
Materials and Methods :We reviewed the records of 135 men. All patients underwent prostate magnetic resonance imaging (MRI). The prostate was divided into eight regions according to the biopsy site. Subsequently, we measured hemorrhage on apparent diffusion coefficient (ADC) values and (choline+creatinine)/citrate ([Cho+Cr]/Cit) ratios in the same regions on the MRI. We investigated the effect of hemorrhage at ADC values and (Cho+Cr)/Cit ratios on MRI and the relationship between prostate biopsy results and MRI findings.
Results:The mean patient age was 68.7 years and the mean time between biopsy and MRI was 23.5 days. The total hemorrhagic score demonstrated no significant associations with intervals from biopsy to MRI. Higher hemorrhagic scores were associated with higher ADC values, prostate cancer, and noncancer groups, respectively (p<0.001). ADC values were lower in tumors than in normal tissue (p<0.001), and ADC values were inversely correlated with tumor Gleason score in biopsy cores (p<0.001). However, (Cho+Cr)/Cit ratios did not exhibit any association with prostate biopsy results and hemorrhage.
Conclusions:Hemorrhage had no significant associations with the interval from biopsy to MRI. ADC values may help to detect prostate cancer and predict the aggressiveness of cancer; however, it is important to consider the bias effect of hemorrhage on the interpretation of MRDW imaging given that hemorrhage affects ADC values.
키워드
Hemorrhage; Magnetic resonance imaging; Magnetic resonance spectroscopy; Prostatic neoplasms
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