Early Sequential Changes in Bladder Function after Partial Bladder Outlet Obstruction in Awake Sprague-Dawley Rats: Focus on the Decompensated Bladder
강용진, 김룡호, 박창신, 신화연, 윤상민, 이택,
소속 상세정보
강용진 ( Kang Yong-Jin )
Inha University College of Medicine Department of Urology
김룡호 ( Jin Long-Hu )
Inha University College of Medicine Department of Urology
박창신 ( Park Chang-Shin )
Inha University College of Medicine Department of Pharmacology
신화연 ( Shin Hwa-Yeon )
Inha University College of Medicine Department of Urology
윤상민 ( Yoon Sang-Min )
Inha University College of Medicine Department of Urology
이택 ( Lee Tack )
Inha University College of Medicine Department of Urology
KMID : 0358320110520120835
Abstract
Purpose: We investigated bladder function, with special focus on initial functional changes, by objective report of decompensated bladder according to the percentage of residual urine volume to bladder capacity in awake, obstructed rats.
Materials and Methods: Thirty rats were randomly subjected to sham operations (n=10) or partial bladder outlet obstruction (BOO, n=20). Cystometric investigations were performed without anesthesia 1 or 2 weeks after BOO surgery. To reduce the influence of confounding factors in awake cystometry, we used simultaneous recordings of intravesical and intraabdominal pressures. Decompensated bladder was defined as the bladder with more than 20% of residual volume compared with bladder capacity.
Results: Compared with that in sham animals, basal pressure was elevated in both BOO groups. Threshold pressure was higher in the 2 week BOO (p<0.01) group. Compliance was decreased in the 1 week BOO group (p<0.01) and increased in the 2 week BOO group (p<0.001). Bladder capacity was not increased in the 1 week BOO group, but was increased in the 2 week BOO group (p<0.01). Decompensation was found in 62.5% of the 1 week BOO group and in 33.3% of the 2 week BOO group.
Conclusions: From the earlier phase, the bladders exhibited serial changes in pressure and volume parameters, and decompensated bladders defined by the percentage of residual volume to bladder capacity could be seen. During the later phase, there was an increasing tendency of compensated bladders, accompanied by the bladders being enlarged and more compliant.
키워드
Detrusor; overactive; Urinary bladder; Urodynamics
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