Efficacy of Alpha Blocker Treatment According to the Degree of Intravesical Prostatic Protrusion Detected by Transrectal Ultrasonography in Patients with Benign Prostatic Hyperplasia
박희영, 이주용, 박성열, 이승욱, 김용태, 최홍용, 문홍상,
소속 상세정보
박희영 ( Park Hee-Young )
Hanyang University College of Medicine Department of Urology
이주용 ( Lee Joo-Yong )
Hanyang University College of Medicine Department of Urology
박성열 ( Park Sung-Yul )
Hanyang University College of Medicine Department of Urology
이승욱 ( Lee Seung-Wook )
Hanyang University College of Medicine Department of Urology
김용태 ( Kim Yong-Tae )
Hanyang University College of Medicine Department of Urology
최홍용 ( Choi Hong-Yong )
Hanyang University College of Medicine Department of Urology
문홍상 ( Moon Hong-Sang )
Hanyang University College of Medicine Department of Urology
KMID : 0358320120530020092
Abstract
Purpose: To analyze the effectiveness of tamsulosin 0.2 mg once daily for 3 months according to the degree of intravesical prostatic protrusion (IPP) in patients with benign prostatic hyperplasia (BPH).
Materials and Methods: A total of 134 BPH patients over 40 years of age treated with tamsulosin 0.2 mg between January 2007 and January 2009 were enrolled retrospectively. The patients were classified into three groups according to the degree of IPP: below 5 mm (group A), between 5 and 10 mm (group B), and over 10 mm (group C). Prostate volume, prostate-specific antigen (PSA), prostatic urethral length (PUL), and prostatic adenoma urethral length (PAUL) were evaluated before treatment. International Prostate Symptom Score and Quality of Life (IPSS/QoL), maximal urine flow rate (Qmax), and postvoid residual (PVR) volume were measured before treatment, and improvement in the three groups was compared after 3 months.
Results: The mean age of the patients was 65.01±7.38 years. Mean IPPs were 0.90±1.39 mm (group A, n=90), 6.92±1.10 mm (group B, n=24), and 16.60±4.06 mm (group C, n=20). Prostate volume, PUL, PAUL, PSA, Qmax, and PVR showed significant correlations with IPP (p<0.05), but not with IPSS/QoL score (p>0.05). Comparison of parameters before and after 3 months showed that medication improved total IPSS and subscores (p<0.001), QoL (p<0.001), Qmax (p<0.001), and PVR (p=0.030) in group A. In group B, it improved total IPSS (p=0.01), irritative subscore (p<0.001), and obstructive subscore (p=0.03). In group C, only total IPSS (p=0.01) and irritative score (p<0.001) were significantly improved.
Conclusions: Tamsulosin may be more effective in improving symptom scores and Qmax in patients with mild IPP than in those with moderate or severe IPP.
키워드
Prostate; Prostatic hyperplasia; Ultrasonography
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