Efficacy and Safety of Propiverine in Children with Overactive Bladder
김우중, 이동기, 이상욱, 이윤경, 이재성, 박관현, 백민기,
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김우중 ( Kim Woo-Jung )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
이동기 ( Lee Dong-Gi )
Kyung Hee University School of Medicine Department of Urology
이상욱 ( Lee Sang-Wook )
Kangwon National University School of Medicine Department of Urology
이윤경 ( Lee Yoon-Kyung )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
이재성 ( Lee Jae-Seung )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
박관현 ( Park Kwan-Hyun )
Seoul Samsung Urology Clinic /Gynecology Health Care Center
백민기 ( Baek Min-Ki )
Sungkyunkwan University School of Medicine Samsung Medical Center Department of Urology
KMID : 0358320120530040275
Abstract
Purpose: Antimuscarinic therapy remains one of the most common forms of therapy for overactive bladder (OAB) in children. However, few clinical studies on the outcomes of antimuscarinics in children with OAB have been published. Therefore, we evaluated the efficacy and safety of propiverine, which is frequently prescribed for the treatment of pediatric OAB.
Materials and Methods: We retrospectively reviewed children with OAB treated with propiverine within the past 5 years. The response rates were compared between the non-urge incontinence (non-UI) and urge incontinence (UI groups). The cumulative response rate by treatment duration was also compared between the two groups.
Results: Among a total of 68 children, 50 children (73.5%) experienced UI. The overall response rate was 86.8%. Functional bladder capacity after treatment was 150 ml, which represented an increase compared with the value (140 ml) before treatment. The voiding frequency per day decreased from 14.0 to 8.5 times. The overall response rate (88.0%) in the non-UI group was not significantly different from that seen in the UI group (83.3%; p>0.05). In non-UI children, the cumulative response rates were 36.0%, 54.0%, 68.0%, 74.0%, 76.0%, and 78.0% at 4, 8, 12, 16, 20, and 24 weeks, respectively. The cumulative response rates in the UI children were 11.1%, 33.3%, 44.4%, 50.0%, 50.0%, and 55.6%, respectively during the same respective time periods. Adverse effects were identified in only two (2.9%) patients, and neither case was severe.
Conclusions: Propiverine is effective and well tolerated as a treatment for children suffering from OAB with or without UI.
키워드
Children; Incontinence; Overactive bladder; PurposePropiverine
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