Wilms’ Tumor with Long-delayed Recurrence: 25 Years after Initial Treatment
이소영, 김규래, Park Jung-Yeol, Ro Jae Y,
소속 상세정보
이소영 ( Lee So-Young )
University of Ulsan College of Medicine Department of Pathology
김규래 ( Kim Kyu-Rae )
University of Ulsan College of Medicine Department of Pathology
( Park Jung-Yeol )
University of Ulsan College of Medicine Department of Obstetrics and Gynecology
( Ro Jae Y )
University of Ulsan College of Medicine Department of Pathology
KMID : 0358320120530040288
Abstract
Wilms’ tumor is one of the most frequent malignant neoplasms in childhood. Advances in treatment modalities such as the combination of chemoradiation therapy with surgery have enhanced overall survival. However, recurrence of Wilms’ tumor is still a problem. In this case, a 28-year-old female had experienced intermittent abdominal pain, and the computed tomography scan showed a huge pelvic mass. The patient had a history of radical nephrectomy for Wilms’ tumor with concurrent chemotherapy at the age of three. The pelvic mass was resected in February 2010 and was confirmed to be a recurrent Wilms’ tumor. The recurrent tumor showed a classic triphasic Wilms’ tumor growth pattern with frequent mitoses and tumor necrosis. Our case is an extraordinary case of a long-delayed recurrent Wilms’ tumor after 25 years, which is the longest disease-free interval ever reported. The possible effects of chemotherapy as well as some other mechanisms of this late relapse are discussed.
키워드
Drug therapy; Late recurrence; Therapeutics; Wilms tumor
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