Docetaxel-Induced Fatal Interstitial Pneumonitis in a Patient with Castration-Resistant Prostate Cancer
민병달, 강호원, 김원태, 김용준, 윤석중, 이상철, 김원재,
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민병달 ( Min Byung-Dal )
Chungbuk National University College of Medicine Department of Urology
강호원 ( Kang Ho-Won )
Chungbuk National University College of Medicine Department of Urology
김원태 ( Kim Won-Tae )
Chungbuk National University College of Medicine Department of Urology
김용준 ( Kim Yong-June )
Chungbuk National University College of Medicine Department of Urology
윤석중 ( Yun Seok-Joong )
Chungbuk National University College of Medicine Department of Urology
이상철 ( Lee Sang-Cheol )
Chungbuk National University College of Medicine Department of Urology
김원재 ( Kim Wun-Jae )
Chungbuk National University College of Medicine Department of Urology
KMID : 0358320120530050371
Abstract
A 69-year-old man with castration-resistant prostate cancer (CRPC) received docetaxel and a corticosteroid. After the third cycle of docetaxel administration, he presented with dyspnea, cough, sputum, and fever of 39.2℃. The chest X-ray and chest computed tomography (CT) revealed a diffuse reticulonodular shadow in both lungs, which suggested interstitial pneumonitis. Initially, we used empiric broad-spectrum antibiotics and high-dose corticosteroids. However, his condition progressively became worse and he was transferred to the intensive care unit, intubated, and placed on mechanical ventilation. He died 4 days after hospital admission. Here we report this case of fatal interstitial pneumonitis after treatment with docetaxel for CRPC. We briefly consider docetaxel-induced pneumonitis to make physicians aware of the possibility of pulmonary toxicity so that appropriate treatment can be begun as soon as possible.
키워드
Docetaxel; Interstitial pneumonitis; Prostatic neoplasms
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