Preoperative Clinical Factors for Diagnosis of Incidental Prostate Cancer in the Era of Tissue-Ablative Surgery for Benign Prostatic Hyperplasia: A Korean Multi-Center Review
유창희, 오철영, 김세중, 김선일, 김영식, 박종연, 성도환, 송윤섭, 양원재, 정현철, 조인래, 조성용, 전상현, 홍성준, 조진선,
소속 상세정보
유창희 ( Yoo Chang-Hee )
Hallym University College of Medicine Department of Urology
오철영 ( Oh Cheol-Young )
Hallym University College of Medicine Department of Urology
김세중 ( Kim Se-Joong )
Ajou University School of Medicine Department of Urology
김선일 ( Kim Sun-Il )
Ajou University School of Medicine Department of Urology
김영식 ( Kim Young-Sik )
National Health Insurance Corporation Ilsan Hospital Department of Urology
박종연 ( Park Jong-Yeon )
University of Ulsan College of Medicine Department of Urology
성도환 ( Seong Do-Hwan )
Inha University College of Medicine Department of Urology
송윤섭 ( Song Yun-Seob )
Soonchunhyang University College of Medicine Department of Urology
양원재 ( Yang Won-Jae )
Soonchunhyang University College of Medicine Department of Urology
정현철 ( Chung Hyun-Chul )
Yonsei University Wonju College of Medicine Department of Urology
조인래 ( Cho In-Rae )
Inje University College of Medicine Department of Urology
조성용 ( Cho Sung-Yong )
Inje University College of Medicine Department of Urology
전상현 ( Cheon Sang-Hyeon )
University of Ulsan College of Medicine Department of Urology
홍성준 ( Hong Sung-Joon )
Yonsei University College of Medicine Department of Urology
조진선 ( Cho Jin-Seon )
Hallym University College of Medicine Department of Urology
KMID : 0358320120530060391
Abstract
Purpose: To identify potential predictive factors of incidental prostate cancer (IPca) in patients considering tissue-ablation treatment for benign prostatic hyperplasia (BPH).
Materials and Methods: From the 11 centers, 1,613 men who underwent transurethral resection of the prostate (TURP) or open prostatectomy were included. Before surgery, prostate biopsy was performed in all patients with prostate-specific antigen (PSA) ≥4.0 ng/ml or with abnormal digital rectal examination (DRE) findings. The patients with prostate cancer preoperatively or with PSA >20 ng/ml were excluded. As predictive factors of IPca, age, body mass index, PSA, DRE, and transrectal ultrasonography (TRUS) findings, including total prostate volume (TPV), transition zone volume (TZV), and the presence of hypoechoic lesions, were reviewed. PSA density (PSAD) and PSAD in the transition zone (PSAD-TZV) were calculated.
Results: IPca was diagnosed in 78 patients (4.8%). DRE findings, PSA, and TZV were independent predictive factors in the multivariate analysis. In the receiver operating characteristic curve analysis of PSA, PSAD, and PSAD-TZV, the area under the curve (AUC) was the largest for PSAD-TZV (AUC, 0.685).
Conclusions: IPca was detected in 4.8% of the population studied. In addition to DRE findings, the combination of TZV and PSA can be useful predictive factors of IPca in patients considering tissue-ablation treatment as well as TURP.
키워드
Prostate neoplasms; Prostatic hyperplasia; Transurethral resection of prostate
원문 및 링크아웃 정보
등재저널 정보