Changes in Prostate Cancer Aggressiveness over a 12-Year Period in Korea
Kim Doe-Jung, Choi Dae-Heon, 임주현, 윤종현, 정인갑, 유달산, 홍준혁, 안한종, 김청수,
소속 상세정보
( Kim Doe-Jung )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
( Choi Dae-Heon )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
임주현 ( Lim Ju-Hyun )
University of Ulsan College of Medicine Asan Medical Center Department of Urology
윤종현 ( Yoon Jong-Hyun )
National Medical Center Department of Urology
정인갑 ( Jeong In-Gab )
University of Ulsan College of Medicine Department of Urology
유달산 ( You Dal-San )
University of Ulsan College of Medicine Department of Urology
홍준혁 ( Hong Jun-Hyuk )
University of Ulsan College of Medicine Department of Urology
안한종 ( Ahn Han-Jong )
University of Ulsan College of Medicine Department of Urology
김청수 ( Kim Choung-Soo )
University of Ulsan College of Medicine Department of Urology
KMID : 0358320120530100680
Abstract
Purpose: To investigate whether tumor aggressiveness in patients with prostate cancer has changed in Korea since the introduction of prostate-specific antigen (PSA) testing.
Materials and Methods: The data from 2,508 patients with pathologically confirmed prostate cancer who underwent radical prostatectomy at Asan Medical Center between 2000 and 2011 were reviewed. The patients were divided into four 3-year time series, and the changes between the groups in terms of serum PSA levels, pathological Gleason score (GS), and pathological stage were assessed. The change in GS over time in organ-confined disease and in patients whose PSA was below 10 ng/ml was also analyzed.
Results: The mean PSA levels dropped significantly over the 12-year period (p<0.001). The frequency of organ-confined disease increased (55.7% vs. 64.7% vs. 62.9% vs. 63.5%, p=0.043). The frequency of patients with a GS of 8 or more decreased (38.9% vs. 25.7% vs. 18.2% vs. 19.7%) and the frequency of patients with a GS of 6 or less increased (15.0% vs. 18.9% vs. 26.7% vs. 18.2%, p=0.003). However, the vast majority (more than 70%) of all cases had a high GS (7 or greater) at all time points. The GS distribution did not change over time in patients whose PSA levels were below 10 ng/ml or in those who had organ-confined disease.
Conclusions: In 2000 to 2011, the preoperative PSA, pathological stage, and pathological GS dropped. However, the majority of the prostate cancers in Korean men were poorly differentiated, even when the patients had organ-confined disease or their PSA levels were less than 10 ng/ml.
키워드
Korea; Neoplasm grading; Prostatic neoplasms
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