Influence of Type of Nocturia and Lower Urinary Tract Symptoms on Therapeutic Outcome in Women Treated With Desmopressin
정재영, 김수진, 조혁진, 홍성후, 이지열, 황태곤, 김세웅,
소속 상세정보
정재영 ( Jeong Jae-Young )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
김수진 ( Kim Su-Jin )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
조혁진 ( Cho Hyuk-Jin )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
홍성후 ( Hong Sung-Hoo )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
이지열 ( Lee Ji-Youl )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
황태곤 ( Hwang Tae-Kon )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
김세웅 ( Kim Sae-Woong )
Catholic University College of Medicine Seoul St. Mary’s Hospital Department of Urology
KMID : 0358320130540020095
Abstract
Purpose: To investigate the type of nocturia and concomitant voiding dysfunction (VD) and the effect of desmopressin treatment on nocturia in women.
Materials and Methods: We reviewed 84 women who experienced more than 2 nocturia episodes as recorded on a pretreatment frequency volume chart and who were treated with desmopressin. All patients underwent history taking, physical examination, urinalysis, International Prostate Symptom Score assessment, completion of a urinary sensation scale, and completion of a 3 day frequency volume chart. Nocturia was divided into nocturnal polyuria (NP), reduced nocturnal bladder capacity (RNBC), and mixed type. After treatment with desmopressin, a reduction in nocturia of over 50% compared with baseline was regarded as effective.
Results: Among 84 women, the most common concomitant VD was overactive bladder (OAB, 60.7%). NP was observed in 70.2% (59/84) of the women, RNBC in 7.1% (6/84), and mixed type in 22.6% (19/84). After medication with desmopressin, 73 women (86.9%) showed a significantly reduced number of nocturia episodes (1.4±1.5) compared with baseline (3.7±1.3, p<0.05). Eleven women (13.1%) did not show improvement. Of the 73 women who showed improvement, 41 women showed a reduction of more than 50% over baseline, and these women had a lower baseline urgency grade.
Conclusions: In the majority of women, nocturia coexisted with other VD such as OAB. Treatment with desmopressin effectively reduced the nocturia. However, other lower urinary tract symptoms (LUTS) such as urgency may reduce the effect of desmopressin. Therefore, consideration of concomitant LUTS seems to be necessary to increase the treatment effect of desmopressin on nocturia in women.
키워드
Deamino arginine vasopressin;Lower urinary tract symptoms;Nocturia;Women
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