Detection of Y Chromosome Microdeletion is Valuable in the Treatment of Patients With Nonobstructive Azoospermia and Oligoasthenoteratozoospermia: Sperm Retrieval Rate and Birth Rate
Choi Don-Kyung, 공인혁, 황진호, 오종진, 홍재엽,
소속 상세정보
( Choi Don-Kyung )
CHA University CHA Bundang Medical Center Department of Urology
공인혁 ( Gong In-Hyuck )
CHA University CHA Bundang Medical Center Department of Urology
황진호 ( Hwang Jin-Ho )
CHA University CHA Bundang Medical Center Department of Urology
오종진 ( Oh Jong-Jin )
CHA University CHA Bundang Medical Center Department of Urology
홍재엽 ( Hong Jae-Yup )
CHA University CHA Bundang Medical Center Department of Urology
KMID : 0358320130540020111
Abstract
Purpose: We evaluated clinical characteristics, sperm retrieval rates, and birth rates in a relatively large number of infertile patients with Y chromosome microdeletions.
Materials and Methods: We retrospectively reviewed clinical data from 213 patients with nonobstructive azoospermia (NOA) and 76 patients with oligoasthenoteratozoospermia (OATS) who were tested for Y chromosome microdeletion from March 2004 to June 2011.
Results: Of the 289 patients, 110 patients presented with Y chromosome microdeletion and 179 patients presented with no microdeletion. Among the patients with Y chromosome microdeletions, 83/110 (75.4%) were NOA patients and 27/110 (24.5%) were OATS patients. After subdividing the patients with Y chromosome microdeletion, 29 had azoospermia factor (AZF)b-c microdeletion and 81 had AZFc microdeletion. The sperm retrieval rate was similar between patients with Y chromosome microdeletion and those with no microdeletion (26.6% vs. 25.6%, p=0.298) after multiple testicular sperm extraction (TESE). Excluding 53 patients who did not undergo TESE, 30 patients were analyzed. All of the 9 men with AZFb-c microdeletion had a complete absence of sperm despite multiple TESE. However, multiple TESE was successful for 9 of 21 patients with only AZFc microdeletion (p=0.041). Twenty patients with Y chromosome microdeletion gave birth.
Conclusions: In NOA and OATS patients, no significant difference in the sperm retrieval rate was shown between patients with Y chromosome microdeletion and those with no microdeletion. Patients with short Y chromosome microdeletion such as AZFc microdeletion have better prognoses for sperm retrieval and an increased chance of conception than do patients with larger microdeletions such as AZFb-c microdeletion.
키워드
Assisted reproductive techniques;Azoospermia;Male infertility;Sperm retrieval;Y chromosome
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