Effect of Type 2 Diabetes Mellitus on Prognosis of Nonmetastatic Renal Cell Cancer
Suer Evren, Ozturk Erdem, Gulpinar Omer, Kayis Aytac, Baltaci Sumer,
소속 상세정보
( Suer Evren )
Ankara University Faculty of Medicine Department of Urology
( Ozturk Erdem )
Ankara University Faculty of Medicine Department of Urology
( Gulpinar Omer )
Ankara University Faculty of Medicine Department of Urology
( Kayis Aytac )
Ankara University Faculty of Medicine Department of Urology
( Baltaci Sumer )
Ankara University Faculty of Medicine Department of Urology
KMID : 0358320130540080499
Abstract
Purpose: We evaluated the prognostic value of type 2 diabetes mellitus (DM) in patients treated surgically for localized renal cell carcinoma (RCC). Materials and Methods: Between 1995 and 2011, 588 patients with renal tumor diagnoses were treated surgically and 492 patients with pathologically confirmed nonmetastatic RCC diagnoses were included in the study. The associations of clinical and pathologic parameters with a type 2 DM diagnosis were evaluated. Kaplan-Meier estimations for disease-specific survival (DSS) and overall survival (OS) were generated according to type 2 DM diagnosis, and the log-rank test was used to compare survival according to the variables. Results: The mean age of the patients was 56.7±12 years (range, 15 to 84 years; median, 58 years) and the mean length of follow-up was 35.9±28 months (range, 1 to 145 months; median, 34.3 months). Of the 492 patients, 62 (12.6%) had a diagnosis of DM at the time of surgery (group I) and 430 did not have DM (group II). The mean age and the incidence of clear cell RCC histological subtype were significantly higher in group I than in group II (p<0.001 and p=0.036, respectively). Although DSS and OS were lower in group I, this difference was not significant. Type 2 DM was not detected as an independent prognostic factor for DSS and OS. Conclusions: This study investigated the role and effect of DM on the prognosis of localized RCC that was treated surgically. The present study did not detect DM as an independent prognostic factor for RCC.
키워드
Prognosis; Renal cell carcinoma; Type 2 diabetes mellitus
원문 및 링크아웃 정보
등재저널 정보