Prostate-Specific Antigen Mass and Free Prostate-Specific Antigen Mass for Predicting the Prostate Volume of Korean Men With Biopsy-Proven Benign Prostatic Hyperplasia
박태용, 채지윤, 김종욱, 김진욱, 오미미, 윤철용, 문두건,
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박태용 ( Park Tae-Yong )
Korea University Guro Hospital Department of Urology
채지윤 ( Chae Ji-Yun )
Korea University Guro Hospital Department of Urology
김종욱 ( Kim Jong-Wook )
Korea University Guro Hospital Department of Urology
김진욱 ( Kim Jin-Wook )
Korea University Guro Hospital Department of Urology
오미미 ( Oh Mi-Mi )
Korea University Guro Hospital Department of Urology
윤철용 ( Yoon Cheol-Yong )
Korea University Guro Hospital Department of Urology
문두건 ( Moon Du-Geon )
Korea University Guro Hospital Department of Urology
KMID : 0358320130540090609
Abstract
Purpose: It has been reported that prostate-specific antigen (PSA) correlates with prostate volume. Recently, some studies have reported that PSA mass (PSA adjusted for plasma volume) is more accurate than PSA at predicting prostate volume. In this study, we analyzed the accuracy of PSA and the related parameters of PSA mass, free PSA (fPSA), and fPSA mass in predicting prostate volume. Materials and Methods: We retrospectively investigated 658 patients who underwent prostate biopsy from 2006 to 2012 and had a confirmed negative biopsy result. International Prostate Symptom Score (IPSS) questionnaire, PSA, fPSA, and prostate volume were investigated. PSA mass and fPSA mass were calculated by use of established formulas. The association between PSA-related parameters and IPSS and prostate volume was assessed by using Pearson correlation coefficient and receiver operating characteristic curves. Results: There was no significant difference between PSA and PSA mass, fPSA, or fPSA mass in predicting prostate volume except in obese patients (p-value of PSA-PSA mass for 40 cm3, 0.54; p-value of fPSA-fPSA mass for 40 cm3, 0.34). fPSA performed significantly better than PSA at predicting prostate volume (p-value for 40 cm3, <0.001). IPSS and the aforementioned PSA-related parameters were not significantly correlated. Conclusions: PSA mass was not a better predictive value than PSA for estimating the prostate volume in Korean men except in obese men. This finding was also applicable to the relationship of fPSA and fPSA mass, which appeared to be more accurate predictors of prostate volume than either PSA or PSA mass.
키워드
Benign prostatic hyperplasia; Prostate-specific antigen; ROC curve
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