Decreased DBC1 Expression Is Associated With Poor Prognosis in Patients With Non-Muscle-Invasive Bladder Cancer
심의재, 이일석, 강호원, 김자영, 김원태, Kim Isaac-Yi, 류근호, 최영현, 문성권, 김용준, 윤석중, 이상철, 김원재,
소속 상세정보
심의재 ( Shim Ui-Jae )
Chungbuk National University College of Medicine Department of Urology
이일석 ( Lee Il-Seok )
Chungbuk National University College of Medicine Department of Urology
강호원 ( Kang Ho-Won )
Chungbuk National University College of Medicine Department of Urology
김자영 ( Kim Ja-Young )
USA Children’s Hospital Boston The Urological Diseases Research Center
김원태 ( Kim Won-Tae )
Chungbuk National University College of Medicine Department of Urology
( Kim Isaac-Yi )
USA Robert Wood Johnson Medical School The Cancer Institute of New Jersey Section of Urologic Oncology
류근호 ( Ryu Keun-Ho )
Chungbuk National University
최영현 ( Choi Yung-Hyun )
Dong-Eui University College of Oriental Medicine Department of Biochemistry
문성권 ( Moon Sung-Kwon )
Chungang University Department of Food and Biotechnology
김용준 ( Kim Yong-June )
Chungbuk National University College of Medicine Department of Urology
윤석중 ( Yun Seok-Joong )
Chungbuk National University College of Medicine Department of Urology
이상철 ( Lee Sang-Cheol )
Chungbuk National University College of Medicine Department of Urology
김원재 ( Kim Wun-Jae )
Chungbuk National University College of Medicine Department of Urology
KMID : 0358320130540090631
Abstract
Purpose: The deleted in bladder cancer 1 (DBC1) gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in bladder cancer (BC). It is suspected that it acts as a tumor suppressor gene, but its prognostic value remains unclear. The aim of the present study was to investigate the value of DBC1 as a prognostic marker in BC. Materials and Methods: The expression of DBC1 was determined by real-time polymerase chain reaction analysis in 344 patients with BC (220 non-muscle-invasive BC [NMIBC] and 124 muscle-invasive BC [MIBC]) and in 34 patients with normal bladder mucosa. The results were compared with clinicopathologic parameters, and the prognostic value of DBC1 was evaluated by Kaplan-Meier analysis and a multivariate Cox regression model. Results: DBC1 expression was significantly decreased in patients with MIBC compared with those diagnosed with NMIBC (p=0.010). Patients with aggressive tumor characteristics had lower DBC1 expression levels in NMIBC (each, p<0.05). By multivariate Cox regression analysis, low DBC1 expression was a predictor of progression to MIBC (hazard ratio, 7.104; p=0.013). Kaplan-Meier estimates revealed a significant difference in tumor recurrence, progression to MIBC, and cancer-specific survival depending on the level of DBC1 expression in NMIBC (log-rank test, each, p<0.05). Conclusions: The expression of DBC1 was associated with tumor aggressiveness, progression to MIBC, and survival in NMIBC. Our results suggest that DBC1 expression can be a useful prognostic marker for patients with NMIBC.
키워드
Bladder cancer; Human DBC1 protein; Prognosis
원문 및 링크아웃 정보
등재저널 정보