The Second-to-Fourth Digit Ratio in Cryptorchidism: A Case-Control Study
Hwang Ha-Wook, 조현욱, 김태우, Yu Dae-Seon, 박진성, Kim Dae-Kyeng, 우승효, Yun Bong-Ju,
소속 상세정보
( Hwang Ha-Wook )
Eulji University School of Medicine Eulji Hospital Department of Urology
조현욱 ( Jo Hyun-Wook )
Eulji University School of Medicine Department of Urology
김태우 ( Kim Tae-woo )
Eulji University Hospital Department of Nursing
( Yu Dae-Seon )
Eulji University School of Medicine Eulji Hospital Department of Urology
박진성 ( Park Jin-Sung )
Eulji University School of Medicine Department of Urology
( Kim Dae-Kyeng )
Eulji University School of Medicine Eulji Hospital Department of Urology
우승효 ( Woo Seung-Hyo )
Eulji University School of Medicine Department of Urology
( Yun Bong-Ju )
Eulji University Hospital Department of Nursing
KMID : 0358320140550020140
Abstract
Purpose: The homeobox (Hox) genes a and d controlling limb and genital development influence the digit ratio and the fetal production of testicular androgen, which may result in testicular descent in boys. To assess whether the digit ratio reflects disease status, we investigated the second and fourth finger lengths in children with cryptorchidism, in children with hydrocele as a disease control, and in healthy controls (boys and girls).
Materials and Methods: One hundred ninety-six children (46 with cryptorchidism, 50 with hydrocele, 50 healthy boys, and 50 healthy girls) who were 6 to 23 months of age were prospectively enrolled. Digit lengths were measured by 2 investigators, and the mean value was recorded.
Results: The second-to-fourth digit ratios (2D:4Ds) of the left hand in the cryptorchidism group, hydrocele group, healthy boys, and healthy girls were 0.958, 0.956, 0.950, and 0.956, respectively. The 2D:4D values of the right hand were 0.946, 0.945, 0.952, and 0.969, respectively. The right and left 2D:4D ratios were not significantly different among groups. The 2D:4D of both hands was not related to age, weight, or height.
Conclusions: According to these results, the 2D:4D was not significantly different in boys with cryptorchidism than in boys with hydrocele or in healthy controls (boys and girls) and failed to reflect disease conditions in the infant period.
키워드
Anthropometry; Child; Cryptorchidism; Fingers
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